5-hydroxytryptamine receptor 2A (Q1949517)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28223

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

1 reference

8 April 2019

Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

virus receptor activity

1 reference

8 April 2019

signal transducer activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28223&geneProductId=UniProtKB:P28223

G-protein alpha-subunit binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

G protein-coupled serotonin receptor activity

5 references

16 July 2018

A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28223&geneProductId=UniProtKB:P28223

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28223&geneProductId=UniProtKB:P28223

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28223&geneProductId=UniProtKB:P28223

16 July 2018

Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28223&geneProductId=UniProtKB:P28223

16 July 2018

The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28223&geneProductId=UniProtKB:P28223

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

neurotransmitter receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

3 references

24 April 2018

p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28223&geneProductId=UniProtKB:P28223

24 April 2018

Identification of a serotonin/glutamate receptor complex implicated in psychosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28223&geneProductId=UniProtKB:P28223

24 April 2018

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28223&geneProductId=UniProtKB:P28223

protein-containing complex binding

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

G protein-coupled receptor activity

G protein-coupled serotonin receptor activity

6 references

8 April 2019

A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

integral component of postsynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

integral component of presynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

integral component of plasma membrane

3 references

8 April 2019

A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

3 references

detection of mechanical stimulus involved in sensory perception of pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

release of sequestered calcium ion into cytosol

regulation of dopamine secretion

IMP

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

phospholipase C-activating serotonin receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

urinary bladder smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

positive regulation of MAP kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

behavioral response to cocaine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

positive regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

positive regulation of kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

positive regulation of phosphatidylinositol biosynthetic process

1 reference

8 April 2019

Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

cellular calcium ion homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

activation of phospholipase C activity

1 reference

8 April 2019

Pharmacological evidence for a functional serotonin-2B receptor in a human uterine smooth muscle cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

detection of temperature stimulus involved in sensory perception of pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

protein localization to cytoskeleton

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

positive regulation of vasoconstriction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

positive regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

negative regulation of potassium ion transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

artery smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

viral entry into host cell

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

Pharmacological evidence for a functional serotonin-2B receptor in a human uterine smooth muscle cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

sensory perception of pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

temperature homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

positive regulation of fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

positive regulation of glycolytic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

negative regulation of synaptic transmission, glutamatergic

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

chemical synaptic transmission

1 reference

16 July 2018

A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28223&geneProductId=UniProtKB:P28223

serotonin receptor signaling pathway

TAS

phospholipase C-activating G protein-coupled receptor signaling pathway

IMP

TAS

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

G protein-coupled receptor signaling pathway

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

regulation of synaptic vesicle exocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

release of sequestered calcium ion into cytosol

3 references

8 April 2019

Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28223

physically interacts with

1 reference

8434

17 August 2016

1 reference

8435

17 August 2016

5-carboxamidotryptamine

1 reference

4

17 August 2016

1 reference

5

17 August 2016

1 reference

107

(+/-)-8-hydroxy-2-(di-N-propylamino)tetralin

17 August 2016

1 reference

7

17 August 2016

1 reference

160

17 August 2016

1 reference

152

17 August 2016

1 reference

34

17 August 2016

1 reference

10

17 August 2016

2 references

163

17 August 2016

155

17 August 2016

1 reference

161

17 August 2016

1 reference

37

17 August 2016

1 reference

109

4-iodo-2,5-dimethoxyphenylisopropylamine

17 August 2016

1 reference

147

17 August 2016

1 reference

39

17 August 2016

1 reference

14

17 August 2016

1 reference

2941

lysergic acid diethylamide

17 August 2016

1 reference

17

17 August 2016

1 reference

150

17 August 2016

1 reference

165

17 August 2016

1 reference

170

17 August 2016

1 reference

171

17 August 2016

1 reference

48

17 August 2016

1 reference

91

17 August 2016

1 reference

50

17 August 2016

1 reference

2

17 August 2016

1 reference

173

17 August 2016

1 reference

23

17 August 2016

1 reference

28

1-(3-trifluoromethylphenyl)piperazine

17 August 2016

1 reference

115

17 August 2016

1 reference

125

17 August 2016

1 reference

168

17 August 2016

1 reference

35

17 August 2016

1 reference

149

17 August 2016

m-chlorophenylpiperazine

1 reference

142

17 August 2016

1 reference

43

17 August 2016

1 reference

56

17 August 2016

1 reference

198

17 August 2016

1 reference

33

17 August 2016

1 reference

7670

17 August 2016

1 reference

144

17 August 2016

1 reference

62

17 August 2016

1 reference

84

17 August 2016

1 reference

202

17 August 2016

1 reference

8182

17 August 2016

1 reference

204

17 August 2016

1 reference

85

17 August 2016

1 reference

186

17 August 2016

1 reference

86

17 August 2016

2 references

88

17 August 2016

197

17 August 2016

1 reference

177

17 August 2016

1 reference

180

17 August 2016

1 reference

7227

17 August 2016

1 reference

206

17 August 2016

1 reference

133

17 August 2016

1 reference

89

17 August 2016

1 reference

134

17 August 2016

1 reference

135

17 August 2016

1 reference

7241

17 August 2016

1 reference

207

17 August 2016

1 reference

7247

17 August 2016

1 reference

47

17 August 2016

1 reference

209

17 August 2016

1 reference

90

17 August 2016

1 reference

92

17 August 2016

1 reference

97

17 August 2016

1 reference

52

17 August 2016

1 reference

187

17 August 2016

1 reference

188

17 August 2016

1 reference

210

17 August 2016

1 reference

189

17 August 2016

1 reference

193

17 August 2016

1 reference

194

17 August 2016

1 reference

195

17 August 2016

1 reference

98

17 August 2016

1 reference

99

17 August 2016

1 reference

175

17 August 2016

1 reference

100

17 August 2016

1 reference

212

17 August 2016

1 reference

213

17 August 2016

1 reference

214

17 August 2016

1 reference

185

17 August 2016

1 reference

7351

17 August 2016

1 reference

57

17 August 2016

1 reference

59

17 August 2016

1 reference

103

17 August 2016

1 reference

83

17 August 2016

1 reference

38

17 August 2016

1 reference

205

17 August 2016

1 reference

8423

17 August 2016

1 reference

96

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1423

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1108

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL422

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL37744

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL708

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL194378

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL42

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL54

aripiprazole lauroxil

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2219425

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201

chlorpromazine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1713

cyclobenzaprine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200636

mesoridazine besylate

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201052

nefazodone hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200492

promazine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200469

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3188993

ziprasidone hydrochloride hydrate

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1375743

Gene Atlas image

PBB GE HTR2A 207135 at fs.png
732 × 530; 11 KB

0 references

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0