Protein kinase, cAMP dependent, catalytic, alpha (Q15329784)

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mammalian protein found in Mus musculus
  • cAMP-dependent protein kinase catalytic subunit alpha
  • PKA C-alpha
  • Prkaca
  • uniprot:P05132
  • sperm cAMP-dependent protein kinase catalytic subunit
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Language Label Description Also known as
English
Protein kinase, cAMP dependent, catalytic, alpha
mammalian protein found in Mus musculus
  • cAMP-dependent protein kinase catalytic subunit alpha
  • PKA C-alpha
  • Prkaca
  • uniprot:P05132
  • sperm cAMP-dependent protein kinase catalytic subunit

Statements

molecular function
protein binding
determination method
IPI
15 references
stated in
UniProt
UniProt protein ID
P05132
retrieved
9 August 2016
language of work or name
English
retrieved
14 February 2019
stated in
Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer
GOA
curator
UniProt
UniProt protein ID
P05132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IPI
retrieved
14 February 2019
stated in
ACTH-induced nucleocytoplasmic translocation of salt-inducible kinase. Implication in the protein kinase A-activated gene transcription in mouse adrenocortical tumor cells
GOA
curator
UniProt
UniProt protein ID
P05132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IPI
retrieved
14 February 2019
stated in
A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation
GOA
curator
UniProt
UniProt protein ID
P05132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IPI
retrieved
14 February 2019
stated in
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IPI
retrieved
14 February 2019
stated in
Rosbin: a novel homeobox-like protein gene expressed exclusively in round spermatids
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IPI
retrieved
14 February 2019
stated in
Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IPI
retrieved
14 February 2019
stated in
An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IPI
retrieved
14 February 2019
stated in
LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IPI
retrieved
14 February 2019
stated in
Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IPI
retrieved
14 February 2019
stated in
Structure and Allostery of the PKA RII  Tetrameric Holoenzyme
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IPI
retrieved
14 February 2019
stated in
Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IPI
retrieved
14 February 2019
stated in
Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IPI
retrieved
14 February 2019
stated in
Probing cellular protein complexes using single-molecule pull-down
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IPI
retrieved
14 February 2019
stated in
Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IPI
protein kinase activity
determination method
IDA
IEA
ISO
6 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IEA
retrieved
14 February 2019
stated in
Biochemical and structural characterization of apolipoprotein A-I binding protein, a novel phosphoprotein with a potential role in sperm capacitation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IDA
retrieved
14 February 2019
stated in
Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IDA
retrieved
14 February 2019
stated in
FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IDA
protein serine/threonine kinase activity
determination method
IDA
IEA
IMP
ISO
TAS
9 references
retrieved
14 February 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
TAS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
ISO
retrieved
14 February 2019
stated in
Conformational preferences in the Ser133-phosphorylated and non-phosphorylated forms of the kinase inducible transactivation domain of CREB
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P05132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IEA
retrieved
14 February 2019
stated in
A kinase-dependent feedforward loop affects CREBB stability and long term memory formation.
GOA
curator
UniProt
UniProt protein ID
P05132
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IDA
retrieved
14 February 2019
stated in
Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IDA
retrieved
14 February 2019
stated in
Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of CREB: A Model for Activator:Coactivator Interactions
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IDA
cell component
biological process
protein phosphorylation
determination method
IDA
IEA
ISO
10 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IEA
retrieved
14 February 2019
stated in
FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IDA
retrieved
14 February 2019
stated in
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IDA
retrieved
14 February 2019
stated in
Biochemical and structural characterization of apolipoprotein A-I binding protein, a novel phosphoprotein with a potential role in sperm capacitation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IDA
retrieved
14 February 2019
stated in
Distribution of RNA binding protein MOEP19 in the oocyte cortex and early embryo indicates pre-patterning related to blastomere polarity and trophectoderm specification
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IDA
retrieved
14 February 2019
stated in
Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IDA
retrieved
14 February 2019
stated in
Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IDA
retrieved
14 February 2019
stated in
Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05132
determination method
IDA

Identifiers

PDB structure ID
 
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