Myosin VIIA (Q14914032)

Ubiquitin-like domain superfamily

1 reference

P-loop containing nucleoside triphosphate hydrolase

1 reference

FERM/acyl-CoA-binding protein superfamily

1 reference

PH-like domain superfamily

1 reference

FERM superfamily, second domain

1 reference

Myosin S1 fragment, N-terminal

1 reference

kinesin motor domain superfamily

1 reference

MyTH4 domain superfamily

1 reference

Band 4.1 domain, protein family

1 reference

Class VII myosin, motor domain, protein family

1 reference

FERM central domain, protein family

1 reference

Myosin head, motor domain, protein family

1 reference

FERM domain, protein family

1 reference

SH3 domain, protein family

1 reference

MyTH4 domain, protein family

1 reference

IQ motif, EF-hand binding site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

1 reference

14 February 2019

protein domain specific binding

1 reference

14 February 2019

Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

calmodulin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

actin filament binding

protein binding

11 references

14 February 2019

PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

PDZD7-MYO7A complex identified in enriched stereocilia membranes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Interactions in the network of Usher syndrome type 1 proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

FERM domain‐containing unconventional myosin VIIA interacts with integrin β5 subunit and regulates αvβ5‐mediated cell adhesion and migration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Interactions in the network of Usher syndrome type 1 proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

microtubule motor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97479&geneProductId=UniProtKB:P97479

1 reference

24 April 2018

microtubule binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97479&geneProductId=UniProtKB:P97479

1 reference

24 April 2018

cytoskeletal motor activity

actin binding

ATP binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

cell component

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

3 references

14 February 2019

ISS

14 February 2019

MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Human Usher 1B/mouse shaker-1: the retinal phenotype discrepancy explained by the presence/absence of myosin VIIA in the photoreceptor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

stereocilium

3 references

24 April 2018

The small GTPase Rac1 regulates auditory hair cell morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97479&geneProductId=UniProtKB:P97479

24 April 2018

Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97479&geneProductId=UniProtKB:P97479

24 April 2018

Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97479&geneProductId=UniProtKB:P97479

photoreceptor connecting cilium

1 reference

14 February 2019

Myosin VIIa participates in opsin transport through the photoreceptor cilium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

lysosomal membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

1 reference

14 February 2019

apical plasma membrane

1 reference

14 February 2019

Mutant myosin VIIa causes defective melanosome distribution in the RPE of shaker-1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

cytoplasm

The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route

14 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Hes1 is a negative regulator of inner ear hair cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Interactions in the network of Usher syndrome type 1 proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

The small GTPase Rac1 regulates auditory hair cell morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

myosin complex

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

stereocilium

PDZD7-MYO7A complex identified in enriched stereocilia membranes.

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

The small GTPase Rac1 regulates auditory hair cell morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

EXP

stereocilium base

1 reference

14 February 2019

Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

biological process

sensory perception

1 reference

14 February 2019

Origin of vestibular dysfunction in Usher syndrome type 1B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

inner ear receptor cell stereocilium organization

1 reference

14 February 2019

A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

pigment granule localization

3 references

14 February 2019

The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

sensory perception of light stimulus

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

post-embryonic animal organ morphogenesis

3 references

14 February 2019

The anatomy and development of the mutants pirouette, shaker-1 and waltzer in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

The pattern of sensorineural degeneration in the cochlea of the deaf shaker-1 mouse: ultrastructural observations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

HEARING DEGENERATION IN SHAKER-1 MOUSE. CORRELATION OF PHYSIOLOGICAL OBSERVATIONS WITH BEHAVIORAL RESPONSES AND WITH COCHLEAR ANATOMY

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

hearing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

13 references

14 February 2019

ISS

14 February 2019

Defective myosin VIIA gene responsible for Usher syndrome type 1B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

A type VII myosin encoded by the mouse deafness gene shaker-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

The pattern of sensorineural degeneration in the cochlea of the deaf shaker-1 mouse: ultrastructural observations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

HEARING DEGENERATION IN SHAKER-1 MOUSE. CORRELATION OF PHYSIOLOGICAL OBSERVATIONS WITH BEHAVIORAL RESPONSES AND WITH COCHLEAR ANATOMY

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Mutation analysis of the mouse myosin VIIA deafness gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

The anatomy and development of the mutants pirouette, shaker-1 and waltzer in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

mechanoreceptor differentiation

1 reference

14 February 2019

Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

auditory receptor cell stereocilium organization

3 references

14 February 2019

Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

phagolysosome assembly

1 reference

14 February 2019

Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

inner ear auditory receptor cell differentiation

3 references

14 February 2019

A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

cell projection organization

1 reference

14 February 2019

Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

inner ear morphogenesis

3 references

14 February 2019

Cattanach's translocation as a tool for studying the action of the shaker-1 gene in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

phagocytosis

1 reference

14 February 2019

Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

inner ear development

4 references

14 February 2019

The anatomy and development of the mutants pirouette, shaker-1 and waltzer in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

The pattern of sensorineural degeneration in the cochlea of the deaf shaker-1 mouse: ultrastructural observations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

HEARING DEGENERATION IN SHAKER-1 MOUSE. CORRELATION OF PHYSIOLOGICAL OBSERVATIONS WITH BEHAVIORAL RESPONSES AND WITH COCHLEAR ANATOMY

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

intracellular protein transport

1 reference

14 February 2019

Myosin VIIa participates in opsin transport through the photoreceptor cilium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

lysosome organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Myosin Va is required for normal photoreceptor synaptic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

Electroretinographic anomalies in mice with mutations in Myo7a, the gene involved in human Usher syndrome type 1B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479

microtubule-based movement

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97479&geneProductId=UniProtKB:P97479

1 reference

24 April 2018

Myosin head, motor domain

has part(s)

1 reference

FERM domain

1 reference

SH3 domain

1 reference

MyTH4 domain

1 reference

IQ motif, EF-hand binding site

1 reference

FERM central domain

1 reference

Band 4.1 domain

1 reference

Class VII myosin, motor domain

1 reference