Solute carrier family 22 (organic cation transporter), member 5 (Q14912768)

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mammalian protein found in Mus musculus

high-affinity sodium-dependent carnitine cotransporter
Slc22a5
solute carrier family 22 member 5
organic cation/carnitine transporter 2
juvenile visceral steatosis

Language	Label	Description	Also known as
English	Solute carrier family 22 (organic cation transporter), member 5	mammalian protein found in Mus musculus	high-affinity sodium-dependent carnitine cotransporter Slc22a5 solute carrier family 22 member 5 organic cation/carnitine transporter 2 juvenile visceral steatosis

Statements

1 reference

25 May 2022

UniProt protein ID

organic cation transport protein/SVOP

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0E8

MFS transporter superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0E8

Major facilitator superfamily domain

1 reference

based on heuristic

inferred from protein domain or family

Sugar transporter, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

PDZ domain binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

transmembrane transporter activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

transporter activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

carnitine transmembrane transporter activity

determination method

5 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Gene-dose effect on carnitine transport activity in embryonic fibroblasts of JVS mice as a model of human carnitine transporter deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Loss of wild-type carrier-mediated L-carnitine transport activity in hepatocytes of juvenile visceral steatosis mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Molecular and functional characterization of organic cation/carnitine transporter family in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

symporter activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

organic anion transmembrane transporter activity

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E8&geneProductId=UniProtKB:Q9Z0E8

determination method

quaternary ammonium group transmembrane transporter activity

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Molecular and functional characterization of organic cation/carnitine transporter family in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

plasma membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

integral component of plasma membrane

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E8&geneProductId=UniProtKB:Q9Z0E8

determination method

basolateral plasma membrane

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

biological process

locomotory behavior

determination method

1 reference

9 May 2019

Prolonged effect of single carnitine administration on fasted carnitine-deficient JVS mice regarding their locomotor activity and energy expenditure

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

adult heart development

determination method

1 reference

9 May 2019

Altered expression of atrial natriuretic peptide and contractile protein genes in hypertrophied ventricle of JVS mice with systemic carnitine deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

sodium ion transport

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

mitochondrion organization

determination method

1 reference

9 May 2019

Mitochondrial abnormalities of muscle tissue in mice with juvenile visceral steatosis associated with systemic carnitine deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

sodium-dependent organic cation transport

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

reproductive structure development

determination method

1 reference

9 May 2019

Dysfunctions of the epididymis as a result of primary carnitine deficiency in juvenile visceral steatosis mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

positive regulation of intestinal epithelial structure maintenance

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

transmembrane transport

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

carnitine transport

determination method

8 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

14 February 2019

Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

14 February 2019

Gene-dose effect on carnitine transport activity in embryonic fibroblasts of JVS mice as a model of human carnitine transporter deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

14 February 2019

Loss of wild-type carrier-mediated L-carnitine transport activity in hepatocytes of juvenile visceral steatosis mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

14 February 2019

Primary defect of juvenile visceral steatosis (jvs) mouse with systemic carnitine deficiency is probably in renal carnitine transport system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

14 February 2019

Carnitine transport defect in fibroblasts of juvenile visceral steatosis (JVS) mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

14 February 2019

Decreased tissue distribution of L-carnitine in juvenile visceral steatosis mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

14 February 2019

Molecular and functional characterization of organic cation/carnitine transporter family in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

carnitine metabolic process

determination method

5 references

9 May 2019

Cardiac hypertrophy in juvenile visceral steatosis (jvs) mice with systemic carnitine deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Abnormal gene expression and regulation in the liver of jvs mice with systemic carnitine deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 Null (OCTN2(-/-)) Mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Animal model of systemic carnitine deficiency: analysis in C3H-H-2 degrees strain of mouse associated with juvenile visceral steatosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Prolonged effect of single carnitine administration on fasted carnitine-deficient JVS mice regarding their locomotor activity and energy expenditure

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

ion transmembrane transport

determination method

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E8&geneProductId=UniProtKB:Q9Z0E8

determination method

cation transmembrane transport

determination method

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E8&geneProductId=UniProtKB:Q9Z0E8

determination method

carnitine transmembrane transport

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

organic anion transport

determination method

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E8&geneProductId=UniProtKB:Q9Z0E8

determination method

carnitine transport

determination method

9 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Primary defect of juvenile visceral steatosis (jvs) mouse with systemic carnitine deficiency is probably in renal carnitine transport system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Gene-dose effect on carnitine transport activity in embryonic fibroblasts of JVS mice as a model of human carnitine transporter deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Loss of wild-type carrier-mediated L-carnitine transport activity in hepatocytes of juvenile visceral steatosis mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Carnitine transport defect in fibroblasts of juvenile visceral steatosis (JVS) mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Decreased tissue distribution of L-carnitine in juvenile visceral steatosis mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Molecular and functional characterization of organic cation/carnitine transporter family in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E8

determination method

sugar transporter, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0E8

major facilitator superfamily domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0E8

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000019044

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000019044

ENSMUSP00000115474

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000115474

ENSMUSP00000118900

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000118900

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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