SMAD family member 3 (Q14903978)

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mammalian protein found in Mus musculus
  • Smad3
  • mMad3
  • mothers against decapentaplegic homolog 3
  • MAD homolog 3
  • mad3
  • mothers against DPP homolog 3
  • Smad 3
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Language Label Description Also known as
English
SMAD family member 3
mammalian protein found in Mus musculus
  • Smad3
  • mMad3
  • mothers against decapentaplegic homolog 3
  • MAD homolog 3
  • mad3
  • mothers against DPP homolog 3
  • Smad 3

Statements

molecular function
protein binding
determination method
IPI
20 references
retrieved
14 February 2019
stated in
PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue
GOA
curator
UniProt
UniProt protein ID
Q8BUN5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination
GOA
curator
UniProt
UniProt protein ID
Q8BUN5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Response gene to complement 32 is essential for fibroblast activation in renal fibrosis
GOA
curator
UniProt
UniProt protein ID
Q8BUN5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Functional interaction between Smad, CREB binding protein, and p68 RNA helicase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Master transcription factors determine cell-type-specific responses to TGF-β signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
retrieved
14 February 2019
stated in
A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
ISO
6 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8BUN5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IEA
retrieved
14 February 2019
stated in
Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins
GOA
curator
UniProt
UniProt protein ID
Q8BUN5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IDA
retrieved
14 February 2019
stated in
The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IDA
retrieved
14 February 2019
stated in
Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IDA
biological process
transforming growth factor beta receptor signaling pathway
determination method
TAS
IDA
IEA
IMP
ISO
8 references
retrieved
14 February 2019
stated in
Receptor-associated Mad homologues synergize as effectors of the TGF-beta response
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
TAS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
ISO
retrieved
14 February 2019
stated in
RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IEA
retrieved
14 February 2019
stated in
RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IDA
retrieved
14 February 2019
stated in
Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IDA
retrieved
14 February 2019
stated in
Cited2 modulates TGF-beta-mediated upregulation of MMP9
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IDA
positive regulation of transcription by RNA polymerase II
determination method
IDA
IGI
IEA
ISO
10 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
ISO
retrieved
14 February 2019
stated in
TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IGI
retrieved
14 February 2019
stated in
DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IGI
retrieved
14 February 2019
stated in
Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IGI
retrieved
14 February 2019
stated in
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IGI
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IEA
retrieved
14 February 2019
stated in
Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells
GOA
curator
UniProt
UniProt protein ID
Q8BUN5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IDA
retrieved
14 February 2019
stated in
The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IDA
retrieved
14 February 2019
stated in
Cited2 modulates TGF-beta-mediated upregulation of MMP9
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IDA
retrieved
14 February 2019
stated in
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5
determination method
IDA

Identifiers

 
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