Interleukin 2 (Q14864519)

http://www.ebi.ac.uk/interpro/protein/P04351

four-helical cytokine-like, core

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04351

Interleukin-2, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

interleukin-2 receptor binding

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

growth factor activity

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

kappa-type opioid receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

glycosphingolipid binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

2 references

13 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Altered antigen presentation in mice lacking H2-O

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

The specificity and orientation of a TCR to its peptide-MHC class II ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Differential T cell costimulatory requirements in CD28-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Critical role of NOD2 in regulating the immune response to Staphylococcus aureus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

biological process

adaptive immune response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

immune system process

1 reference

14 February 2019

positive regulation of interferon-gamma production

1 reference

14 February 2019

FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

negative regulation of lymphocyte proliferation

1 reference

14 February 2019

A function for interleukin 2 in Foxp3-expressing regulatory T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

regulation of T cell homeostatic proliferation

IMP

1 reference

14 February 2019

A function for interleukin 2 in Foxp3-expressing regulatory T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

extrinsic apoptotic signaling pathway in absence of ligand

1 reference

14 February 2019

Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

positive regulation of isotype switching to IgG isotypes

1 reference

14 February 2019

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

positive regulation of transcription by RNA polymerase II

IMP

1 reference

14 February 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

positive regulation of activated T cell proliferation

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

negative regulation of T-helper 17 cell differentiation

1 reference

14 February 2019

MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

positive regulation of tyrosine phosphorylation of STAT protein

IGI

3 references

regulation of signaling receptor activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

negative regulation of protein phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

positive regulation of protein phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

G protein-coupled receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

positive regulation of cytosolic calcium ion concentration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

protein kinase C-activating G protein-coupled receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

positive regulation of T cell proliferation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

14 February 2019

IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

positive regulation of T cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

positive regulation of regulatory T cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

negative regulation of heart contraction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

positive regulation of dendritic spine development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351

Interleukin-2, conserved site

has part(s)

1 reference

stated in

InterPro Release 71.0