P21 (RAC1) activated kinase 1 (Q7118116)

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mammalian protein found in Homo sapiens
  • PAK1
  • serine/threonine-protein kinase PAK 1
  • PAK-1
  • STE20 homolog, yeast
  • p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
  • p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
  • p21-activated kinase 1
  • alpha-PAK
  • p21 protein (Cdc42/Rac)-activated kinase 1
  • p65-PAK
  • PAK1 protein, human
edit
Language Label Description Also known as
English
P21 (RAC1) activated kinase 1
mammalian protein found in Homo sapiens
  • PAK1
  • serine/threonine-protein kinase PAK 1
  • PAK-1
  • STE20 homolog, yeast
  • p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
  • p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
  • p21-activated kinase 1
  • alpha-PAK
  • p21 protein (Cdc42/Rac)-activated kinase 1
  • p65-PAK
  • PAK1 protein, human

Statements

molecular function
protein binding
determination method
IPI
47 references
retrieved
8 April 2019
stated in
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family
GOA
curator
UniProt
UniProt protein ID
Q13153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion
GOA
curator
UniProt
UniProt protein ID
Q13153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization
GOA
curator
UniProt
UniProt protein ID
Q13153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Scrib regulates PAK activity during the cell migration process
GOA
curator
UniProt
UniProt protein ID
Q13153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck
GOA
curator
UniProt
UniProt protein ID
Q13153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
A small GTPase‑like protein fragment of Mycoplasma promotes tumor cell migration and proliferation in vitro via interaction with Rac1 and Stat3.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Induction of apoptosis by p110C requires mitochondrial translocation of the proapoptotic BCL-2 family member BAD
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Nox1 activation by βPix and the role of Ser-340 phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
A genetically encoded photoactivatable Rac controls the motility of living cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Invasion of breast cancer cells into collagen matrix requires TGF-α and Cdc42 signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Localized Rac activation dynamics visualized in living cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
CRIPak, a novel endogenous Pak1 inhibitor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Blebbishields, the emergency program for cancer stem cells: sphere formation and tumorigenesis after apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Affixin activates Rac1 via betaPIX in C2C12 myoblast
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
CRIPak, a novel endogenous Pak1 inhibitor
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
retrieved
8 April 2019
stated in
A small GTPase‑like protein fragment of Mycoplasma promotes tumor cell migration and proliferation in vitro via interaction with Rac1 and Stat3.
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IPI
protein serine/threonine kinase activity
determination method
IDA
TAS
EXP
IEA
10 references
retrieved
5 June 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13153&geneProductId=UniProtKB:Q13153
determination method
TAS
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q13153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13153&geneProductId=UniProtKB:Q13153
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13153&geneProductId=UniProtKB:Q13153
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13153&geneProductId=UniProtKB:Q13153
determination method
IEA
retrieved
5 June 2018
stated in
CRIPak, a novel endogenous Pak1 inhibitor
GOA
curator
UniProt
UniProt protein ID
Q13153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13153&geneProductId=UniProtKB:Q13153
determination method
IDA
retrieved
5 June 2018
stated in
Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation
GOA
curator
UniProt
UniProt protein ID
Q13153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13153&geneProductId=UniProtKB:Q13153
determination method
IDA
retrieved
5 June 2018
stated in
VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13153&geneProductId=UniProtKB:Q13153
determination method
EXP
retrieved
5 June 2018
stated in
Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13153&geneProductId=UniProtKB:Q13153
determination method
EXP
retrieved
5 June 2018
stated in
The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13153&geneProductId=UniProtKB:Q13153
determination method
EXP
retrieved
5 June 2018
stated in
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13153&geneProductId=UniProtKB:Q13153
determination method
EXP
protein serine/threonine kinase activity
determination method
EXP
IBA
IDA
IEA
TAS
10 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IEA
retrieved
8 April 2019
stated in
MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response
GOA
curator
UniProt
UniProt protein ID
Q13153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IDA
retrieved
8 April 2019
stated in
CRIPak, a novel endogenous Pak1 inhibitor
GOA
curator
UniProt
UniProt protein ID
Q13153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IDA
retrieved
8 April 2019
stated in
Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation
GOA
curator
UniProt
UniProt protein ID
Q13153
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
IBA
retrieved
8 April 2019
stated in
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
EXP
retrieved
8 April 2019
stated in
The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13153
determination method
EXP
cell component
biological process
Gene Atlas image
PBB GE PAK1 209615 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
C515903
subject named as
PAK1 protein, human
0 references
RefSeq protein ID
Freebase ID
/m/03cr6x3
0 references
Microsoft Academic ID
24901178
0 references
2910350067
0 references
PDB structure ID
 
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q7118116&oldid=2022909514"