Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis (Q24336049)

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4 March 2020

title

Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis (English)

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4 March 2020

3

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4 March 2020

Thomas Schweiger

18

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4 March 2020

Konrad Hoetzenecker

19

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4 March 2020

Balázs Hegedűs

21

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Christoph Röcken

26

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4 March 2020

Kurt Anderson

29

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Owen J Sansom

30

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Henning Walczak

31

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4 March 2020

author name string

Silvia von Karstedt

1

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4 March 2020

Annalisa Conti

2

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4 March 2020

Antonella Montinaro

4

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4 March 2020

Torsten Hartwig

5

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4 March 2020

Johannes Lemke

6

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4 March 2020

Karen Legler

7

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Andrew D Campbell

9

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Lucia Taraborrelli

10

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Anne Grosse-Wilde

11

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4 March 2020

Johannes F Coy

12

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4 March 2020

Mona A El-Bahrawy

13

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Frank Bergmann

14

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Ronald Koschny

15

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4 March 2020

Jens Werner

16

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4 March 2020

Tom M Ganten

17

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4 March 2020

Istvan Kenessey

20

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4 March 2020

Michael Bergmann

22

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4 March 2020

Charlotte Hauser

23

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4 March 2020

Thomas Becker

25

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Holger Kalthoff

27

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Franka Annewanter

8

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Jan-Hendrik Egberts

24

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Anna Trauzold

28

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language of work or name

English

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publication date

2 April 2015

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4 March 2020

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4 March 2020

volume

27

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4 March 2020

page(s)

561-573

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4 March 2020

issue

4

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Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor.

4 March 2020

cites work

1 reference

12 December 2020

Safety and antitumor activity of recombinant soluble Apo2 ligand

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12 December 2020

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

1 reference

12 December 2020

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

1 reference

12 December 2020

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

1 reference

12 December 2020

Localized Rac activation dynamics visualized in living cells

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12 December 2020

Effects and expression of TRAIL and its apoptosis-promoting receptors in human pancreatic cancer.

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12 December 2020

Modulation of tumor necrosis factor apoptosis-inducing ligand- induced NF-kappa B activation by inhibition of apical caspases

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Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

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12 December 2020

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

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Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice

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12 December 2020

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

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12 December 2020

Genetic and epigenetic alterations in colon cancer

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12 December 2020

Focus on pancreas cancer

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12 December 2020

Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells

1 reference

12 December 2020

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

1 reference

12 December 2020

Cytogenetics and molecular genetics of lung cancer

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12 December 2020

TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.

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12 December 2020

Expression of TRAIL and TRAIL death receptors in stage III non-small cell lung cancer tumors

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12 December 2020

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

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12 December 2020

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

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Expression of TRAIL and TRAIL receptors in normal and malignant tissues

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Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells

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Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand

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12 December 2020

TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma

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Differential expression of TRAIL and its receptors in benign and malignant prostate tissues

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12 December 2020

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

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Bortezomib sensitizes primary human astrocytoma cells of WHO grades I to IV for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.

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Requirement for Rac1 in a K-ras induced lung cancer in the mouse.

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TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis

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TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development

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TRAIL-induced survival and proliferation of SCLC cells is mediated by ERK and dependent on TRAIL-R2/DR5 expression in the absence of caspase-8.

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12 December 2020

Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4

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12 December 2020

Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis

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Mammalian Rho GTPases: new insights into their functions from in vivo studies

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Rac activation and inactivation control plasticity of tumor cell movement

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

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Targeting RAS and PI3K in lung cancer.

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Prognostic value of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors in renal cell cancer

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Prognostic significance of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in patients with breast cancer.

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Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors

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Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

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Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

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Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells

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Biosensors for characterizing the dynamics of rho family GTPases in living cells

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12 December 2020

TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5.

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12 December 2020

Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact

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The plasticity of cytoskeletal dynamics underlying neoplastic cell migration

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12 December 2020

Early requirement of Rac1 in a mouse model of pancreatic cancer.

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12 December 2020

Inhibition of Ras for cancer treatment: the search continues

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12 December 2020

KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.

1 reference

12 December 2020

Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells

1 reference

12 December 2020

miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma.

1 reference

12 December 2020

β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity

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12 December 2020

Surgical implantation of an abdominal imaging window for intravital microscopy

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12 December 2020

ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation

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RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms

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Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation

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Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells

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12 December 2020

Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

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12 December 2020

The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues

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12 December 2020

Getting TRAIL back on track for cancer therapy

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ras oncogenes in human cancer: a review

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12 December 2020

Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas

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Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

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12 December 2020

The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain

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Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

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12 December 2020

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

1 reference

12 December 2020

10.1016/J.CCELL.2015.02.014

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