Insulin receptor substrate 1 (Q1665322)

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mammalian protein found in Homo sapiens
  • IRS1
  • IRS-1
  • insulin receptor substrate 1
  • uniprot:P35568
  • Insulin Receptor Substrate Protein
  • Insulin Receptor Substrate Proteins
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Language Label Description Also known as
English
Insulin receptor substrate 1
mammalian protein found in Homo sapiens
  • IRS1
  • IRS-1
  • insulin receptor substrate 1
  • uniprot:P35568
  • Insulin Receptor Substrate Protein
  • Insulin Receptor Substrate Proteins

Statements

molecular function
protein binding
determination method
IPI
23 references
retrieved
8 April 2019
stated in
S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2
GOA
curator
UniProt
UniProt protein ID
P35568
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart
GOA
curator
UniProt
UniProt protein ID
P35568
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2
GOA
curator
UniProt
UniProt protein ID
P35568
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation
GOA
curator
UniProt
UniProt protein ID
P35568
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains
GOA
curator
UniProt
UniProt protein ID
P35568
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein
GOA
curator
UniProt
UniProt protein ID
P35568
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Shc and CEACAM1 interact to regulate the mitogenic action of insulin
GOA
curator
UniProt
UniProt protein ID
P35568
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Locating a protein-protein interaction in living cells via split Renilla luciferase complementation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Structure homology and interaction redundancy for discovering virus-host protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Split luciferase as an optical probe for detecting protein-protein interactions in mammalian cells based on protein splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Association of insulin receptor substrate 1 with simian virus 40 large T antigen
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
cell component
biological process
insulin receptor signaling pathway
determination method
IDA
IEA
IMP
IPI
5 references
retrieved
21 June 2018
stated in
Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain
GOA
curator
UniProt
UniProt protein ID
P35568
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
21 June 2018
stated in
Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains
GOA
curator
UniProt
UniProt protein ID
P35568
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
21 June 2018
stated in
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568
determination method
IMP
retrieved
21 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568
determination method
IEA
retrieved
21 June 2018
stated in
Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568
determination method
IDA
insulin receptor signaling pathway
determination method
IBA
IDA
IEA
IMP
IPI
6 references
retrieved
8 April 2019
stated in
Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain
GOA
curator
UniProt
UniProt protein ID
P35568
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains
GOA
curator
UniProt
UniProt protein ID
P35568
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IPI
retrieved
8 April 2019
stated in
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IEA
retrieved
8 April 2019
stated in
Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568
determination method
IBA
Gene Atlas image
PBB GE IRS1 204686 at fs.png
732 × 530; 11 KB
0 references

Identifiers

 
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