Synuclein alpha interacting protein (Q21127234)

mammalian protein found in Homo sapiens

SNCAIP
Alpha-synuclein-interacting protein
synphilin-1

Language	Label	Description	Also known as
English	Synuclein alpha interacting protein	mammalian protein found in Homo sapiens	SNCAIP Alpha-synuclein-interacting protein synphilin-1

Statements

1 reference

13 November 2019

1 reference

1 December 2016

1 reference

13 November 2019

1 reference

13 November 2019

6 references

8 April 2019

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

8 April 2019

Parkin accumulation in aggresomes due to proteasome impairment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

8 April 2019

Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

8 April 2019

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

8 April 2019

Analysis of synphilin-1 and synuclein interactions by yeast two-hybrid beta-galactosidase liquid assay

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

8 April 2019

Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method

IPI

ubiquitin protein ligase binding

1 reference

8 April 2019

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method

IPI

identical protein binding

1 reference

8 April 2019

Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

3 references

8 April 2019

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

8 April 2019

Siah-1 facilitates ubiquitination and degradation of synphilin-1

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

1 reference

8 April 2019

Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

1 reference

8 April 2019

Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

1 reference

8 April 2019

Synaptic vesicle trafficking and Parkinson's disease

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method

IDA

cytoplasmic ribonucleoprotein granule

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method

IDA

biological process

regulation of inclusion body assembly

1 reference

8 April 2019

BAG5 inhibits parkin and enhances dopaminergic neuron degeneration

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method

IDA

dopamine metabolic process

1 reference

8 April 2019

Siah-1 facilitates ubiquitination and degradation of synphilin-1

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

1 reference

8 April 2019

Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method

IDA

regulation of neurotransmitter secretion

1 reference

8 April 2019

Siah-1 facilitates ubiquitination and degradation of synphilin-1

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method

IDA

Identifiers

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30 May 2020

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30 May 2020

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13 November 2019

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20 March 2016

language of work or name

English

Synuclein alpha interacting protein (Q21127234)

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Synuclein alpha interacting protein (Q21127234)

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Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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