Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication (Q24317181)

identical protein binding

GOA release 2020-03-11

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GOA release 2020-03-11

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Yuan-Yuan Xie

1

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Chen-Jie Zhou

2

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Zi-Ren Zhou

3

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Jing Hong

4

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Mei-Xia Che

5

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Qing-Shan Fu

6

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Ai-Xin Song

7

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Dong-Hai Lin

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Hong-Yu Hu

Synphilin-1 is present in Lewy bodies in Parkinson's disease

9

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language of work or name

English

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publication date

January 2010

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published in

FASEB Journal

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volume

24

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page(s)

196-205

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issue

1

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cites work

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Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

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Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells

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Analysis of synphilin-1 and synuclein interactions by yeast two-hybrid beta-galactosidase liquid assay

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Aggresomes, inclusion bodies and protein aggregation

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Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients

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The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

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