bortesomib (Q419319)

inferred from InChIKey ^Saesneg

defnydd

cyffur meddygol

0 ffynonellau

adeiledd gemegol

Bortezomib.svg
512 × 357; 6 KB

1 ffynhonnell

mewnforiwyd o

Wicipedia Almaeneg

màs

384.197 uned Dalton

1 ffynhonnell

PubChem ^Saesneg

PubChem CID ^Saesneg

179324-69-7 (Saesneg)

19 Hydref 2016

stereoisomer of ^Saesneg

N-[(1R)-1-Borono-3-methylbutyl]-Nalpha-(pyrazine-2-carbonyl)-D-phenylalaninamide ^Saesneg

2 ffynonellau

inferred from InChIKey ^Saesneg

inferred from InChI ^Saesneg

N-[(1S)-1-Borono-3-methylbutyl]-Nalpha-(pyrazine-2-carbonyl)-L-phenylalaninamide ^Saesneg

1 ffynhonnell

inferred from InChIKey ^Saesneg

fformwla gemegol

C₁₉H₂₅BN₄O₄

1 ffynhonnell

PubChem ^Saesneg

PubChem CID ^Saesneg

179324-69-7 (Saesneg)

19 Tachwedd 2016

SMILES

B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O

1 ffynhonnell

PubChem ^Saesneg

PubChem CID ^Saesneg

179324-69-7 (Saesneg)

19 Tachwedd 2016

isomeric SMILES ^Saesneg

B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O

1 ffynhonnell

PubChem ^Saesneg

PubChem CID ^Saesneg

179324-69-7 (Saesneg)

19 Tachwedd 2016

cynhwysyn actif yn

Bortezomib Accord ^Saesneg

1 ffynhonnell

European Medicines Agency product number ^Saesneg

EMEA/H/C/003984

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/003984/human_med_001882.jsp

22 Mawrth 2017

Bortezomib Hospira ^Saesneg

1 ffynhonnell

European Medicines Agency product number ^Saesneg

EMEA/H/C/004207

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/004207/human_med_001995.jsp

22 Mawrth 2017

Bortezomib Sun ^Saesneg

1 ffynhonnell

European Medicines Agency product number ^Saesneg

EMEA/H/C/004076

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/004076/human_med_001996.jsp

22 Mawrth 2017

Velcade ^Saesneg

1 ffynhonnell

RxNorm ^Saesneg

RxNorm ID ^Saesneg

356733

14 Chwefror 2018

World Health Organisation international non-proprietary name ^Saesneg

bortezomib (Saesneg)

1 ffynhonnell

ChEBI ^Saesneg

ChEBI ID ^Saesneg

52717

bortezomib (Saesneg)

19 Hydref 2016

1 ffynhonnell

NDF-RT ^Saesneg

13 Rhagfyr 2016

amyloidosis ^Saesneg

1 ffynhonnell

2 Hydref 2018

plasmacytoma ^Saesneg

1 ffynhonnell

2 Hydref 2018

mantle cell lymphoma ^Saesneg

1 ffynhonnell

2 Hydref 2018

Waldenström macroglobulinemia ^Saesneg

1 ffynhonnell

2 Hydref 2018

precursor T-cell lymphoblastic leukemia ^Saesneg

1 ffynhonnell

2 Hydref 2018

lewcemia myeloid aciwt

1 ffynhonnell

2 Hydref 2018

lymffoma ddi-Hodgkin

1 ffynhonnell

2 Hydref 2018

plasma cell leukemia ^Saesneg

1 ffynhonnell

2 Hydref 2018

B-cell lymphoma ^Saesneg

1 ffynhonnell

2 Hydref 2018

diffuse large B-cell lymphoma ^Saesneg

1 ffynhonnell

2 Hydref 2018

significant drug interaction ^Saesneg

ffosffenytoin

side effect ^Saesneg

peripheral neuropathy ^Saesneg

1 ffynhonnell

manylrwydd y gosodiad

hypothetically ^Saesneg

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

ffenytoin

side effect ^Saesneg

peripheral neuropathy ^Saesneg

1 ffynhonnell

manylrwydd y gosodiad

hypothetically ^Saesneg

adweithia'n ffisegol gyda

A reference set of clinically relevant adverse drug-drug interactions ^Saesneg

Proteasome 20S subunit beta 5 ^Saesneg

rôl y pwnc

enzyme inhibitor ^Saesneg

1 ffynhonnell

dynodwr Llawlyfr Ffarmacoleg Ligand

IUPHAR/BPS Guide to PHARMACOLOGY ^Saesneg

6391

categori beichiogrwydd Awstralia C

17 Awst 2016

categori beichiogrwydd

1 ffynhonnell

mewnforiwyd o

Wicipedia Saesneg

categori beichiogrwydd Unol Daleithiau America D

1 ffynhonnell

mewnforiwyd o

Wicipedia Saesneg

LiverTox likelihood score ^Saesneg

LiverTox toxicity likelihood category C ^Saesneg

1 ffynhonnell

LiverTox ^Saesneg

8 Ebrill 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Bortezomib

last update ^Saesneg

30 Medi 2017

gwneuthurwr

Pfizer

1 ffynhonnell

https://www.pfizer.com/products/product-list

rôl y pwnc

antineoplastic ^Saesneg

1 ffynhonnell

15 Mawrth 2018

Bortezomib

0 ffynonellau

Identifiers

InChI

InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1

1 ffynhonnell

PubChem ^Saesneg

PubChem CID ^Saesneg

179324-69-7 (Saesneg)

19 Tachwedd 2016

InChIKey ^Saesneg

2 ffynonellau

PubChem ^Saesneg

PubChem CID ^Saesneg

179324-69-7 (Saesneg)

19 Tachwedd 2016

ChEBI release 2020-09-01 ^Saesneg

Rhif Cofrestru CAS

179324-69-7

2 ffynonellau

Global Substance Registration System ^Saesneg

UNII ^Saesneg

69G8BD63PP

bortezomib (Saesneg)

19 Tachwedd 2016

InChIKey ^Saesneg

CAS Common Chemistry ^Saesneg

9 Ebrill 2021

https://commonchemistry.cas.org/detail?cas_rn=179324-69-7

ChemSpider ID ^Saesneg

343402

1 ffynhonnell

ChemSpider ^Saesneg

ChemSpider ID ^Saesneg

343402

Bortezomib (Saesneg)

19 Tachwedd 2016

PubChem CID ^Saesneg

2 ffynonellau

PubChem ^Saesneg

PubChem CID ^Saesneg

179324-69-7 (Saesneg)

19 Tachwedd 2016

matched by identifier from ^Saesneg

InChIKey

InChIKey ^Saesneg

Reaxys registry number ^Saesneg

8723817

1 ffynhonnell

ChEBI ^Saesneg

ChEBI ID ^Saesneg

52717

bortezomib (Saesneg)

19 Hydref 2016

ChEBI ID ^Saesneg

52717

mapping relation type ^Saesneg

exact match ^Saesneg

2 ffynonellau

ChEMBL ^Saesneg

ChEMBL ID ^Saesneg

CHEMBL325041

BORTEZOMIB (Saesneg)

InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1

19 Tachwedd 2016

matched by identifier from ^Saesneg

International Chemical Identifier ^Saesneg

InChI

ChEMBL ID ^Saesneg

CHEMBL325041

1 ffynhonnell

ChEMBL ^Saesneg

ChEMBL ID ^Saesneg

CHEMBL325041

BORTEZOMIB (Saesneg)

19 Tachwedd 2016

UniChem compound ID ^Saesneg

503765

1 ffynhonnell

splash10-016r-1397000000-e168634cfe7e1453d742

UniChem ^Saesneg

SPLASH ^Saesneg

0 ffynonellau

dynodwr HSDB

7666

1 ffynhonnell

Hazardous Substances Data Bank ^Saesneg

28 Hydref 2019

BORTEZOMIB (Saesneg)

10 Mai 2021

DSSTox substance ID ^Saesneg

DTXSID3040980

2 ffynonellau

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard ^Saesneg

matched by identifier from ^Saesneg

InChIKey

InChIKey ^Saesneg

DSSTOX compound identifier ^Saesneg

DTXCID1020980

0 ffynonellau

LiverTox ID ^Saesneg

Bortezomib

0 ffynonellau

NSC number ^Saesneg

681239

0 ffynonellau

EC number ^Saesneg

605-854-3

0 ffynonellau

ECHA Substance Infocard ID ^Saesneg

100.125.601

1 ffynhonnell

ECHA Substance Infocard database ^Saesneg

ECHA Substance Infocard ID ^Saesneg

100.125.601

27 Rhagfyr 2018

N,N',N''-((2S,2'S,2''S)-(((1R,1'R,1''R)-(1,3,5,2,4,6-trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(1-oxo-3-phenylpropane-2,1-diyl))tris(pyrazine-2-carboxamide) (Saesneg)

dyfyniad

CAS no.: 179324-69-7 (Saesneg)

Cod yr ATC

L01XX32

1 ffynhonnell

Dynodwr Drugbank (Alberta)

DrugBank ^Saesneg

00188