Adrenoceptor beta 2 (Q287961)

http://www.ebi.ac.uk/interpro/protein/P07550

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.3.5

hierarchical database ID heuristic

2 October 2019

based on heuristic

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

adenylate cyclase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

adrenergic receptor activity

1 reference

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07550

beta2-adrenergic receptor activity

4 references

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07550

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07550

23 May 2017

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07550

23 May 2017

Structure of an Arrestin2-Clathrin Complex Reveals a Novel Clathrin Binding Domain That Modulates Receptor Trafficking

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07550

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

protein homodimerization activity

1 reference

8 April 2019

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

potassium channel regulator activity

1 reference

8 April 2019

G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

13 references

8 April 2019

The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

Beta-2 adrenergic receptor mediated ERK activation is regulated by interaction with MAGI-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

signal transducer activity

IPI

1 reference

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07550

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

norepinephrine binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

1 reference

8 April 2019

Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

beta2-adrenergic receptor activity

6 references

8 April 2019

Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

Structure of an Arrestin2-Clathrin Complex Reveals a Novel Clathrin Binding Domain That Modulates Receptor Trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

protein-containing complex binding

IBA

1 reference

8 April 2019

Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

apical plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

1 reference

8 April 2019

Role of clathrin-mediated endocytosis in agonist-induced down-regulation of the beta2-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

3 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

clathrin-coated vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

integral component of plasma membrane

3 references

8 April 2019

Structure of an Arrestin2-Clathrin Complex Reveals a Novel Clathrin Binding Domain That Modulates Receptor Trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

3 references

8 April 2019

Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

positive regulation of autophagosome maturation

biological process

1 reference

8 April 2019

β-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

regulation of sodium ion transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

endosome to lysosome transport

1 reference

8 April 2019

Role of clathrin-mediated endocytosis in agonist-induced down-regulation of the beta2-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

receptor-mediated endocytosis

1 reference

8 April 2019

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

cell surface receptor signaling pathway

1 reference

8 April 2019

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

regulation of systemic arterial blood pressure by norepinephrine-epinephrine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

regulation of smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

1 reference

23 May 2017

Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07550

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

adenylate cyclase-activating adrenergic receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

desensitization of G protein-coupled receptor signaling pathway by arrestin

1 reference

8 April 2019

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

positive regulation of MAPK cascade

1 reference

8 April 2019

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

positive regulation of bone mineralization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

activation of adenylate cyclase activity

1 reference

8 April 2019

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

brown fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

activation of transmembrane receptor protein tyrosine kinase activity

1 reference

8 April 2019

The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

positive regulation of protein ubiquitination

1 reference

8 April 2019

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

negative regulation of multicellular organism growth

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

1 reference

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07550

diet induced thermogenesis

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

positive regulation of lipophagy

1 reference

8 April 2019

β-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

protein deubiquitination

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

membrane organization

1 reference

8 April 2019

adrenergic receptor signaling pathway

1 reference

8 April 2019

Structure of an Arrestin2-Clathrin Complex Reveals a Novel Clathrin Binding Domain That Modulates Receptor Trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

blood vessel diameter maintenance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

positive regulation of mini excitatory postsynaptic potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

positive regulation of protein serine/threonine kinase activity

1 reference

8 April 2019

Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

response to psychosocial stress

IGI

1 reference

8 April 2019

Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

positive regulation of cAMP-dependent protein kinase activity

1 reference

8 April 2019

Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

positive regulation of AMPA receptor activity

1 reference

8 April 2019

Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07550

physically interacts with

IGI

1 reference

7479

17 August 2016

1 reference

557

17 August 2016

1 reference

3465

17 August 2016

1 reference

7455

17 August 2016

1 reference

7445

17 August 2016

1 reference

7543

17 August 2016

1 reference

7250

17 August 2016

1 reference

7353

17 August 2016

1 reference

3466

17 August 2016

1 reference

479

17 August 2016

1 reference

536

17 August 2016

1 reference

559

17 August 2016

1 reference

535

17 August 2016

1 reference

556

17 August 2016

1 reference

91

17 August 2016

1 reference

558

17 August 2016

1 reference

560

17 August 2016

1 reference

563

17 August 2016

1 reference

548

17 August 2016

1 reference

549

17 August 2016

1 reference

550

17 August 2016

1 reference

569

17 August 2016

1 reference

551

17 August 2016

1 reference

552

17 August 2016

1 reference

7207

17 August 2016

1 reference

8035

17 August 2016

1 reference

570

17 August 2016

1 reference

553

17 August 2016

1 reference

554

17 August 2016

1 reference

2561

17 August 2016

1 reference

564

17 August 2016

1 reference

7297

17 August 2016

1 reference

547

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1197051

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1094966

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1095607

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL679

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1198857

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1437

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL211456

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL49080

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1094785

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1240967

isoproterenol hydrochloride

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1711

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL160519

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200405

carteolol hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201002

dipivefrin hydrochloride

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200833

DL-dobutamine hydrochloride

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200418

esmolol hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201115

levobunolol hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201177

propafenone hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201063

propranolol hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1671

sotalol hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1700

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200870

Gene Atlas image

PBB GE ADRB2 206170 at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P07550

1 reference

GPCR, rhodopsin-like, 7TM

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07550

Identifiers

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

Transporter Classification Database ID

English

9.A.14.3.5

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023