lecithin-cholesterol acyltransferase (Q424716)

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mammalian protein found in Homo sapiens

phospholipid-cholesterol acyltransferase
LCAT
phosphatidylcholine--sterol O-acyltransferase
testicular secretory protein Li 24
phosphatidylcholine-sterol acyltransferase

Language	Label	Description	Also known as
English	lecithin-cholesterol acyltransferase	mammalian protein found in Homo sapiens	phospholipid-cholesterol acyltransferase LCAT phosphatidylcholine--sterol O-acyltransferase testicular secretory protein Li 24 phosphatidylcholine-sterol acyltransferase

Statements

1 reference

13 November 2019

UniProt protein ID

Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04180

Alpha/Beta hydrolase fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04180

LCAT protein.png
1,920 × 975; 735 KB

0 references

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

O-acyltransferase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

apolipoprotein A-I binding

determination method

1 reference

8 April 2019

Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol vesicles

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

protein binding

determination method

3 references

8 April 2019

Interaction of lecithin:cholesterol acyltransferase (LCAT).alpha 2-macroglobulin complex with low density lipoprotein receptor-related protein (LRP). Evidence for an alpha 2-macroglobulin/LRP receptor-mediated system participating in LCAT clearance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol vesicles

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

acyltransferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

phosphatidylcholine-sterol O-acyltransferase activity

determination method

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

Role of the interfacial binding domain in the oxidative susceptibility of lecithin:cholesterol acyltransferase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

The high-resolution crystal structure of human LCAT

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

A protein cofactor of lecithin:cholesterol acyltransferase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

high-density lipoprotein particle

determination method

1 reference

8 April 2019

Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

extracellular exosome

determination method

extracellular space

determination method

4 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

Cloning and expression of human lecithin-cholesterol acyltransferase cDNA

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

A protein cofactor of lecithin:cholesterol acyltransferase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

extracellular exosome

determination method

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

biological process

steroid metabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

regulation of high-density lipoprotein particle assembly

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

cholesterol transport

determination method

1 reference

8 April 2019

Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

cholesterol metabolic process

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

The high-resolution crystal structure of human LCAT

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

A protein cofactor of lecithin:cholesterol acyltransferase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

cholesterol esterification

determination method

3 references

8 April 2019

The high-resolution crystal structure of human LCAT

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

Cloning and expression of human lecithin-cholesterol acyltransferase cDNA

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

A protein cofactor of lecithin:cholesterol acyltransferase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

very-low-density lipoprotein particle remodeling

determination method

1 reference

8 April 2019

Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

phospholipid metabolic process

determination method

1 reference

8 April 2019

A protein cofactor of lecithin:cholesterol acyltransferase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

lipoprotein biosynthetic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

cholesterol homeostasis

determination method

1 reference

8 April 2019

A protein cofactor of lecithin:cholesterol acyltransferase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

phosphatidylcholine biosynthetic process

determination method

1 reference

8 April 2019

Role of the interfacial binding domain in the oxidative susceptibility of lecithin:cholesterol acyltransferase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

phosphatidylcholine metabolic process

determination method

1 reference

8 April 2019

The high-resolution crystal structure of human LCAT

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

reverse cholesterol transport

determination method

1 reference

8 April 2019

A protein cofactor of lecithin:cholesterol acyltransferase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

high-density lipoprotein particle remodeling

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

Formation of spherical, reconstituted high density lipoproteins containing both apolipoproteins A-I and A-II is mediated by lecithin:cholesterol acyltransferase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

Remodeling of HDL remnants generated by scavenger receptor class B type I

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

ApoA-I structure on discs and spheres. Variable helix registry and conformational states

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

8 April 2019

A protein cofactor of lecithin:cholesterol acyltransferase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04180

determination method

http://purl.uniprot.org/uniprot/P04180

1 reference

Identifiers.org

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000264005

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000264005

ENSP00000458141

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000458141

ENSP00000459014

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000459014

ENSP00000459291

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000459291

ENSP00000460653

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000460653

ENSP00000463220

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463220

ENSP00000464651

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464651

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(14 entries)

dewiki Lecithin-Cholesterin-Acyltransferase
enwiki Lecithin–cholesterol acyltransferase
eswiki Lecitin Colesterol Acil Transferasa
fawiki لسیتین-کلسترول اسیل‌ترانسفراز
frwiki Lécithine-cholestérol acyltransférase
itwiki Fosfatidilcolina-sterolo O-aciltransferasi
nlwiki Lecithine-cholesterol-acyltransferase
plwiki Acylotransferaza lecytynowo-cholesterolowa
ptwiki Lecitina-colesterol aciltransferase
ruwiki Лецитинхолестеринацилтрансфераза
shwiki Fosfatidilholin—sterol O-aciltransferaza
srwiki Fosfatidilholin—sterol O-aciltransferaza
trwiki Lesitin kolesterol asiltransferaz
ukwiki Лецитинхолестеролацилтрансфераза

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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