remdésivir (Q28209496)

https://www.clinicaltrialsarena.com/news/china-covid-19-trials/

https://www.marketwatch.com/story/these-nine-companies-are-working-on-coronavirus-treatments-or-vaccines-heres-where-things-stand-2020-03-06?mod=home-page

formule chimique

C₂₇H₃₅N₆O₈P

0 référence

SMILES canonique

Nc3ncnn2c3ccc2C(C#N)(C1O)OC(C1O)CO[P](=O)(NC(C)C(=O)OCC(CC)CC)Oc4ccccc4

0 référence

SMILES isomérique

CCC(CC)COC(=O)[C@H](C)N[P@](=O)(OC[C@@H]1[C@H]([C@H]([C@](O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4

0 référence

effet secondaire

hépatotoxicité

nature de la déclaration

souvent

1 référence

https://www.biospace.com/article/data-from-gilead-s-compassionate-use-of-remdesivir-for-covid-19-looks-promising/

maladie traitée

Covid-19

contesté par

Organisation mondiale de la santé

1 référence

https://www.nbcnews.com/health/health-news/remdesivir-shouldn-t-be-used-hospitalized-covid-19-patients-who-n1248320

22 janvier 2022

fièvre hémorragique Ebola

The antiviral remdesivir should not be used as treatment for hospitalized Covid-19 patients, the World Health Organization said Thursday, only a month after the Food and Drug Administration approved the drug to treat patients over age 12 who are hospitalized with Covid-19. (anglais)

1 référence

https://www.drugsincontext.com/the-journey-of-remdesivir:-from-ebola-to-covid-19/

22 janvier 2022

statut légal (médicament)

Although remdesivir performed well in preclinical studies, it did not meet efficacy endpoints in a randomized trial conducted during an Ebola outbreak. (anglais)

voie d'administration

perfusion intraveineuse

0 référence

avertissement encadré

1 référence

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

titre

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (anglais)

décrit à l'URL

https://pubmed.ncbi.nlm.nih.gov/34252308/

0 référence

https://github.com/croningp/ChemputerAntiviralXDL/tree/master/Remdesivir

1 référence

https://twitter.com/Chemputation/status/1255645127281979397

caractérisé par

ineffective drug ^anglais

déclaration soutenue par

Organisation mondiale de la santé

20 novembre 2020

2 références

https://www.who.int/news-room/feature-stories/detail/who-recommends-against-the-use-of-remdesivir-in-covid-19-patients

22 janvier 2022

WHO has issued a conditional recommendation against the use of remdesivir in hospitalized patients, regardless of disease severity, as there is currently no evidence that remdesivir improves survival and other outcomes in these patients. (anglais)

https://pubmed.ncbi.nlm.nih.gov/34252308/

22 janvier 2022

fièvre hémorragique Ebola

However, the clinical efficacy of remdesivir for COVID-19 remains contentious, as several trials have not found statistically significant differences in either time to clinical improvement or mortality between remdesivir-treated and control groups. (anglais)

ineffective drug ^anglais

maladie traitée

1 référence

https://www.drugsincontext.com/the-journey-of-remdesivir:-from-ebola-to-covid-19/

22 janvier 2022