The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. (Q42064781)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17097561%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

title

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized (English)

1 reference

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21 December 2019

1 reference

9

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21 December 2019

Mark F van Delft

1

1 reference

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21 December 2019

Kylie D. Mason

3

1 reference

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21 December 2019

Suzanne Cory

10

1 reference

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21 December 2019

Jerry Adams

11

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21 December 2019

Andrew W. Roberts

12

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21 December 2019

David C Huang

13

1 reference

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21 December 2019

Peter E Czabotar

6

0 references

Andrew Wei

object named as

Andrew H Wei

2

0 references

Clare L Scott

object named as

Clare L Scott

8

0 references

author name string

Cassandra J Vandenberg

4

1 reference

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21 December 2019

Lin Chen

5

1 reference

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21 December 2019

Simon N Willis

7

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21 December 2019

publication date

1 November 2006

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21 December 2019

1 reference

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21 December 2019

volume

10

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21 December 2019

page(s)

389-399

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21 December 2019

issue

5

1 reference

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Promoting apoptosis as a strategy for cancer drug discovery

21 December 2019

cites work

1 reference

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Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation

5 June 2018

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The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006.

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

5 June 2018

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Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1

5 June 2018

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5 June 2018

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

5 June 2018

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Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma

5 June 2018

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

5 June 2018

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

5 June 2018

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Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

5 June 2018

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VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis

5 June 2018

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Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

5 June 2018

1 reference

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The Bcl-2 family: roles in cell survival and oncogenesis.

5 June 2018

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DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells

5 June 2018

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

5 June 2018

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Alterations in the apoptotic machinery and their potential role in anticancer drug resistance

5 June 2018

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

5 June 2018

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The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

5 June 2018

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Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins

5 June 2018

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Integral role of Noxa in p53-mediated apoptotic response

5 June 2018

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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

5 June 2018

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A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells

5 June 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

5 June 2018

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Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs

5 June 2018

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A view to a kill: ligands for Bcl-2 family proteins

5 June 2018

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MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis

5 June 2018

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Large-scale analysis of the human and mouse transcriptomes

5 June 2018

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5 June 2018

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5 June 2018

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Protein-protein interfaces: mimics and inhibitors

5 June 2018

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Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

5 June 2018

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

5 June 2018

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

5 June 2018

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5 June 2018

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Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

5 June 2018

1 reference

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Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

5 June 2018

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Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

5 June 2018

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

5 June 2018

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BH3-Only proteins-essential initiators of apoptotic cell death

5 June 2018

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Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.

5 June 2018

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Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

5 June 2018

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

5 June 2018

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5 June 2018

The Hallmarks of Cancer

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Mcl-1 deficiency results in peri-implantation embryonic lethality

5 June 2018

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

5 June 2018

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The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

5 June 2018

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Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.

5 June 2018

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

5 June 2018

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MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

5 June 2018

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

5 June 2018

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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

5 June 2018

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Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

5 June 2018

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Assaying cytochrome C translocation during apoptosis

17 August 2018

1 reference

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Identification of chelerythrine as an inhibitor of BclXL function

17 August 2018

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Stable suppression of tumorigenicity by virus-mediated RNA interference

17 August 2018

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Genetic analysis of chemoresistance in primary murine lymphomas.

17 August 2018

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Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17097561

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17097561

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Involvement of the bcl-2 gene in human follicular lymphoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17097561

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2006.08.027

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17097561%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17097561%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

1 reference