Proliferating cell nuclear antigen (Q418732)

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mammalian protein found in Homo sapiens
  • proliferating cell nuclear antigen
  • cyclin
  • PCNA
  • DNA polymerase delta auxiliary protein
edit
Language Label Description Also known as
English
Proliferating cell nuclear antigen
mammalian protein found in Homo sapiens
  • proliferating cell nuclear antigen
  • cyclin
  • PCNA
  • DNA polymerase delta auxiliary protein

Statements

molecular function
protein binding
determination method
IPI
60 references
retrieved
1 January 2018
stated in
Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
A defined human system that supports bidirectional mismatch-provoked excision
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA.
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
The ADP-ribosyltransferase PARP10/ARTD10 interacts with proliferating cell nuclear antigen (PCNA) and is required for DNA damage tolerance
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Replication-independent chromatin loading of Dnmt1 during G2 and M phases
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Inhibition of homologous recombination by the PCNA-interacting protein PARI
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Spartan/C1orf124 is important to prevent UV-induced mutagenesis
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Metnase promotes restart and repair of stalled and collapsed replication forks
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
ING2 controls the progression of DNA replication forks to maintain genome stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Complex formation between hepatitis C virus core protein and p21Waf1/Cip1/Sdi1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Functional roles of p12, the fourth subunit of human DNA polymerase delta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Proliferating cell nuclear antigen in the cytoplasm interacts with components of glycolysis and cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Proliferating cell nuclear antigen is a novel inhibitory ligand for the natural cytotoxicity receptor NKp44.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Proliferating cell nuclear antigen (PCNA) may function as a double homotrimer complex in the mammalian cell
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Proteomic analysis of human Angiogenin interactions reveals cytoplasmic PCNA as a putative binding partner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Proteomic analysis of p16ink4a-binding proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Novel interaction between proliferating cell nuclear antigen and HLA I on the surface of tumor cells inhibits NK cell function through NKp44.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
A protein domain-based interactome network for C. elegans early embryogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
retrieved
1 January 2018
stated in
The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IPI
cell component
nucleus
determination method
IBA
IDA
IEA
6 references
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IEA
retrieved
1 January 2018
stated in
CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IDA
retrieved
1 January 2018
stated in
Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells
GOA
curator
UniProt
UniProt protein ID
P12004
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IDA
retrieved
1 January 2018
stated in
GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004
determination method
IBA
biological process
Gene Atlas image
PBB GE PCNA 201202 at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D018809
subject named as
Proliferating Cell Nuclear Antigen
0 references
MeSH tree code
D12.776.660.740
0 references
D23.050.290.750
0 references
D23.101.140.600
0 references
PDB structure ID
 
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