Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells (Q40507353)

21 September 2017

Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells (English)

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21 September 2017

Daqing Wu

1

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21 September 2017

Chittam U Thakore

2

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21 September 2017

Ginger G Wescott

3

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21 September 2017

James A McCubrey

4

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21 September 2017

David M Terrian

5

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21 September 2017

language of work or name

English

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publication date

1 November 2004

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21 September 2017

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21 September 2017

23

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21 September 2017

53

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21 September 2017

8659-8672

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207900

21 September 2017

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cites work

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21 January 2018

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Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

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Myc confers androgen-independent prostate cancer cell growth

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Activated R-ras, Rac1, PI 3-kinase and PKCepsilon can each restore cell spreading inhibited by isolated integrin beta1 cytoplasmic domains

21 January 2018

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The anchoring protein RACK1 links protein kinase Cepsilon to integrin beta chains. Requirements for adhesion and motility

21 January 2018

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Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

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The development of androgen-independent prostate cancer

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Fibronectin Protects Prostate Cancer Cells from Tumor Necrosis Factor-α-induced Apoptosis via the AKT/Survivin Pathway

21 January 2018

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The alpha5beta1 integrin selectively enhances epidermal growth factor signaling to the phosphatidylinositol-3-kinase/Akt pathway in intestinal epithelial cells

21 January 2018

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Is the Achilles' heel for prostate cancer therapy a gain of function in androgen receptor signaling?

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Protein kinase C: a target for anticancer drugs?

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Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

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Regulation of beta1C and beta1A integrin expression in prostate carcinoma cells.

21 January 2018

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Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.

21 January 2018

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Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation

21 January 2018

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

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Phosphatidylinositol 3-kinase/Akt stimulates androgen pathway through GSK3beta inhibition and nuclear beta-catenin accumulation

21 January 2018

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Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway

21 January 2018

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Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

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Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin

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Regulation of caveolin-1 expression and secretion by a protein kinase cepsilon signaling pathway in human prostate cancer cells

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Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

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7 January 2021

Catalytic cleavage of the androgen receptor messenger RNA and functional inhibition of androgen receptor activity by a hammerhead ribozyme

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In vitro evidence for complex modes of nuclear beta-catenin signaling during prostate growth and tumorigenesis

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Ligand-dependent inhibition of beta-catenin/TCF signaling by androgen receptor

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7 January 2021

Differential translocation of protein kinase C epsilon during HeLa cell adhesion to a gelatin substratum

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7 January 2021

Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer

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7 January 2021

Androgen Receptors in Prostate Cancer

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

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Inhibition of LncaP prostate cancer cells by means of androgen receptor antisense oligonucleotides

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Inhibition of LNCaP prostate tumor growth in vivo by an antisense oligonucleotide directed against the human androgen receptor

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7 January 2021

Integrins and prostate cancer metastases.

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7 January 2021

A census of human cancer genes

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7 January 2021

Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia

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7 January 2021

Emerging targets in the AKT pathway for treatment of androgen-independent prostatic adenocarcinoma

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7 January 2021

Curbing the nuclear activities of beta-catenin. Control over Wnt target gene expression

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7 January 2021

RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix

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7 January 2021

Identification of c-MYC as a target of the APC pathway

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7 January 2021

Integrins: bidirectional, allosteric signaling machines

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7 January 2021

PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1.

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7 January 2021

PKC epsilon controls the traffic of beta1 integrins in motile cells

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7 January 2021

Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer

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7 January 2021

Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells

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7 January 2021

Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling

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7 January 2021

Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state

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7 January 2021

PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic

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7 January 2021

Beta1-integrin and PTEN control the phosphorylation of protein kinase C.

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7 January 2021

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

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7 January 2021

Beta-catenin binds to the activation function 2 region of the androgen receptor and modulates the effects of the N-terminal domain and TIF2 on ligand-dependent transcription

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7 January 2021

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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7 January 2021

Inhibitors of integrins

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7 January 2021

Molecular characterization of human prostate carcinoma cell lines

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7 January 2021

Integrin-linked kinase (ILK): a "hot" therapeutic target

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207900

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Dimensions Publication ID

21 September 2017

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