Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. (Q34184917)

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1 November 2019

review article

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title

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy (English)

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1 November 2019

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6

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1 November 2019

Richard A. Franklin

7

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1 November 2019

James A. McCubrey

8

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1 November 2019

author name string

Chang F

1

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1 November 2019

Lee JT

2

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1 November 2019

Navolanic PM

3

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1 November 2019

Steelman LS

4

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1 November 2019

Shelton JG

5

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1 November 2019

publication date

1 March 2003

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1 November 2019

number of pages

14

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inferred from page(s)

published in

Leukemia

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1 November 2019

volume

17

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1 November 2019

page(s)

590-603

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1 November 2019

issue

3

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2402824

1 November 2019

exact match

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7 January 2021

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7 January 2021

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Bcl-2 targets the protein kinase Raf-1 to mitochondria

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Abrogation of c-Raf expression induces apoptosis in tumor cells.

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7 January 2021

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

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7 January 2021

BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1

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7 January 2021

Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals

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7 January 2021

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7 January 2021

Cooperating oncogenes converge to regulate cyclin/cdk complexes.

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A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.

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7 January 2021

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Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

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7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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7 January 2021

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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7 January 2021

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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7 January 2021

Differentiation and malignant transformation: two roads diverged in a wood

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An activated mutant of R-Ras inhibits cell death caused by cytokine deprivation in BaF3 cells in the presence of IGF-I

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7 January 2021

Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways

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7 January 2021

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

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7 January 2021

Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression

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7 January 2021

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

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7 January 2021

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

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7 January 2021

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

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7 January 2021

Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockou

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7 January 2021

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

1 reference

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7 January 2021

3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth

1 reference

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7 January 2021

Mechanisms of apoptosis by the tyrphostin AG957 in hematopoietic cells

1 reference

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7 January 2021

Mechanism of action of the immunosuppressant rapamycin

1 reference

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7 January 2021

Downregulation of Akt1 inhibits anchorage-independent cell growth and induces apoptosis in cancer cells

1 reference

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7 January 2021

Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival

1 reference

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7 January 2021

Blocking oncogenic Ras signaling for cancer therapy

1 reference

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7 January 2021

Farnesyl transferase inhibitors: a novel targeted tnerapy for cancer

1 reference

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7 January 2021

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

1 reference

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7 January 2021

Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype

1 reference

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7 January 2021

A Phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma

1 reference

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7 January 2021

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1 reference

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7 January 2021

Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

1 reference

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7 January 2021

v-Crk activates the phosphoinositide 3-kinase/AKT pathway by utilizing focal adhesion kinase and H-Ras

1 reference

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7 January 2021

A distinct class of dominant negative Ras mutants: cytosolic GTP-bound Ras effector domain mutants that inhibit Ras signaling and transformation and enhance cell adhesion

1 reference

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7 January 2021

Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells

1 reference

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7 January 2021

Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts

1 reference

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7 January 2021

Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel

1 reference

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7 January 2021

Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402824

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 November 2019

0 references

1 reference