Notch receptor 1 (Q4044985)

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mammalian protein found in Homo sapiens
  • Notch homolog 1, translocation-associated
  • NOTCH1
  • notch 1
  • neurogenic locus notch homolog protein 1
  • translocation-associated notch protein TAN-1
  • Receptor, Notch1
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Language Label Description Also known as
English
Notch receptor 1
mammalian protein found in Homo sapiens
  • Notch homolog 1, translocation-associated
  • NOTCH1
  • notch 1
  • neurogenic locus notch homolog protein 1
  • translocation-associated notch protein TAN-1
  • Receptor, Notch1

Statements

part of
molecular function
protein binding
determination method
IPI
28 references
retrieved
9 May 2019
stated in
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis
GOA
curator
UniProt
UniProt protein ID
P46531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
GOA
curator
UniProt
UniProt protein ID
P46531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters
GOA
curator
UniProt
UniProt protein ID
P46531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors
GOA
curator
UniProt
UniProt protein ID
P46531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
GOA
curator
UniProt
UniProt protein ID
P46531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function
GOA
curator
UniProt
UniProt protein ID
P46531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis.
GOA
curator
UniProt
UniProt protein ID
P46531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
The CD46-Jagged1 interaction is critical for human TH1 immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Notch signaling mediates hypoxia-induced tumor cell migration and invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Direct inhibition of the NOTCH transcription factor complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Notch is a direct negative regulator of the DNA-damage response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Notch1 augments NF-kappaB activity by facilitating its nuclear retention
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Cyclin C is a haploinsufficient tumour suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
retrieved
9 May 2019
stated in
A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IPI
cell component
biological process
aortic valve morphogenesis
determination method
IEA
IMP
ISS
TAS
6 references
retrieved
1 January 2018
stated in
NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
ISS
retrieved
1 January 2018
stated in
Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IMP
retrieved
1 January 2018
stated in
NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IMP
retrieved
1 January 2018
stated in
Mutations in NOTCH1 cause aortic valve disease
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IEA
Notch signaling pathway
determination method
IBA
IDA
IEA
IMP
TAS
7 references
retrieved
9 May 2019
stated in
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function
GOA
curator
UniProt
UniProt protein ID
P46531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
TAS
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
TAS
retrieved
9 May 2019
stated in
Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells
GOA
curator
UniProt
UniProt protein ID
P46531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P46531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IEA
retrieved
9 May 2019
stated in
Notch signaling induces cell cycle arrest in small cell lung cancer cells
GOA
curator
UniProt
UniProt protein ID
P46531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531
determination method
IBA
Gene Atlas image
PBB GE NOTCH1 218902 at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D051881
subject named as
Receptor, Notch1
0 references
PDB structure ID
 
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