Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies (Q36642953)

15 August 2017

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title

Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies (English)

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15 August 2017

Christopher H George

1

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15 August 2017

Hala Jundi

2

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15 August 2017

N Lowri Thomas

3

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15 August 2017

Debra L Fry

4

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15 August 2017

F Anthony Lai

5

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15 August 2017

1 November 2006

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Journal of Molecular and Cellular Cardiology

15 August 2017

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15 August 2017

42

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15 August 2017

34-50

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15 August 2017

1

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Task Force on Sudden Cardiac Death, European Society of Cardiology.

15 August 2017

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

7 January 2021

Cardiac channelopathies

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Molecular and cellular mechanisms of cardiac arrhythmias

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

7 January 2021

From molecule to malady

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Cardiac excitation-contraction coupling

7 January 2021

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Calcium currents and arrhythmias: insights from molecular biology

7 January 2021

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Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism

7 January 2021

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Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations

7 January 2021

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Ryanodine receptor/Ca2+ release channels and their regulation by endogenous effectors

7 January 2021

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Ryanodine receptor calcium release channels

7 January 2021

1 reference

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Molecular regulation of cardiac ryanodine receptor ion channel

7 January 2021

1 reference

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Macromolecular complexes regulating cardiac ryanodine receptor function.

7 January 2021

1 reference

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Toward a molecular understanding of the structure-function of ryanodine receptor Ca2+ release channels: perspectives from recombinant expression systems.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Regulation of ryanodine receptors by FK506 binding proteins

7 January 2021

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Absence of calsequestrin 2 causes severe forms of catecholaminergic polymorphic ventricular tachycardia

7 January 2021

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Abnormal interactions of calsequestrin with the ryanodine receptor calcium release channel complex linked to exercise-induced sudden cardiac death

7 January 2021

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A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel

7 January 2021

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Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban

7 January 2021

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A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.

7 January 2021

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Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy

7 January 2021

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Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-t

7 January 2021

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Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling.

7 January 2021

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Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

7 January 2021

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Catecholaminergic polymorphic ventricular tachycardia in children. A 7-year follow-up of 21 patients

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ryanodine receptor dysfunction in arrhythmia and sudden cardiac death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Cardiac and skeletal muscle disorders caused by mutations in the intracellular Ca2+ release channels.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Mechanisms of Disease: ryanodine receptor defects in heart failure and fatal arrhythmia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Catecholaminergic polymorphic ventricular tachycardia: recent mechanistic insights

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ryanodine receptor channelopathies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Clinical implications of cardiac ryanodine receptor/calcium release channel mutations linked to sudden cardiac death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Screening for ryanodine receptor type 2 mutations in families with effort-induced polymorphic ventricular arrhythmias and sudden death: early diagnosis of asymptomatic carriers.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Molecular genetics of exercise-induced polymorphic ventricular tachycardia: identification of three novel cardiac ryanodine receptor mutations and two common calsequestrin 2 amino-acid polymorphisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

A novel mutation in FKBP12.6 binding region of the human cardiac ryanodine receptor gene (R2401H) in a Japanese patient with catecholaminergic polymorphic ventricular tachycardia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Denaturing HPLC-based approach for detecting RYR2 mutations involved in malignant arrhythmias

7 January 2021

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Spectrum and frequency of cardiac channel defects in swimming-triggered arrhythmia syndromes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Catecholaminergic polymorphic ventricular tachycardia, recurrent syncope, and implantable loop recorder

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Targeted mutational analysis of the RyR2-encoded cardiac ryanodine receptor in sudden unexplained death: a molecular autopsy of 49 medical examiner/coroner's cases

7 January 2021

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Pathogenesis of unexplained drowning: new insights from a molecular autopsy

7 January 2021

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Juvenile sudden death in a family with polymorphic ventricular arrhythmias caused by a novel RyR2 gene mutation: evidence of specific morphological substrates.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Spectrum and prevalence of cardiac ryanodine receptor (RyR2) mutations in a cohort of unrelated patients referred explicitly for long QT syndrome genetic testing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Unusual clinical presentation in a family with catecholaminergic polymorphic ventricular tachycardia due to a G14876A ryanodine receptor gene mutation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patients.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

A novel mutation (Arg169Gln) of the cardiac ryanodine receptor gene causing exercise-induced bidirectional ventricular tachycardia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Identification of novel missense mutations of cardiac ryanodine receptor gene in exercise-induced sudden death at autopsy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Genotypic heterogeneity and phenotypic mimicry among unrelated patients referred for catecholaminergic polymorphic ventricular tachycardia genetic testing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Human cardiac ryanodine receptor mutations in ion channel disorders in Japan

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Composite polymorphisms in the ryanodine receptor 2 gene associated with arrhythmogenic right ventricular cardiomyopathy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

The CpG dinucleotide and human genetic disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Postmortem molecular screening in unexplained sudden death.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Sudden cardiac death in younger adults: autopsy diagnosis as a tool for preventive medicine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Genetics of arrhythmogenic right ventricular cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Intracellular calcium handling dysfunction and arrhythmogenesis: a new challenge for the electrophysiologist.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Etiopathogenesis of arrhythmogenic right ventricular cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Arrhythmogenic right ventricular cardiomyopathy: moving toward mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

The pore structure of the closed RyR1 channel

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

The skeletal muscle Ca2+ release channel has an oxidoreductase-like domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Role of malignant hyperthermia domain in the regulation of Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Amino acids 1-1,680 of ryanodine receptor type 1 hold critical determinants of skeletal type for excitation-contraction coupling. Role of divergence domain D2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Deletion of amino acids 1641-2437 from the foot region of skeletal muscle ryanodine receptor alters the conduction properties of the Ca release channel

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Two regions of the ryanodine receptor involved in coupling with L-type Ca2+ channels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

RyR1/RyR3 chimeras reveal that multiple domains of RyR1 are involved in skeletal-type E-C coupling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Postulated role of interdomain interaction within the ryanodine receptor in Ca(2+) channel regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Functional interactions between cytoplasmic domains of the skeletal muscle Ca2+ release channel

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

A Ca2+-binding domain in RyR1 that interacts with the calmodulin binding site and modulates channel activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Mutational analysis of putative calcium binding motifs within the skeletal ryanodine receptor isoform, RyR1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Identification of a key determinant of ryanodine receptor type 1 required for activation by 4-chloro-m-cresol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Amino acid residues Gln4020 and Lys4021 of the ryanodine receptor type 1 are required for activation by 4-chloro-m-cresol.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ryanodine receptor point mutant E4032A reveals an allosteric interaction with ryanodine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Molecular identification of the ryanodine receptor Ca2+ sensor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Interaction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Role of the Met3534-Ala4271 region of the ryanodine receptor in the regulation of Ca2+ release induced by calmodulin binding domain peptide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ca(2+) inactivation sites are located in the COOH-terminal quarter of recombinant rabbit skeletal muscle Ca(2+) release channels (ryanodine receptors).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Evidence for a role of C-terminus in Ca(2+) inactivation of skeletal muscle Ca(2+) release channel (ryanodine receptor)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Oligomerization of the cardiac ryanodine receptor C-terminal tail

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Evidence for a role of C-terminal amino acid residues in skeletal muscle Ca2+ release channel (ryanodine receptor) function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Excitation--contraction uncoupling by a human central core disease mutation in the ryanodine receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

The transmembrane segment of ryanodine receptor contains an intracellular membrane retention signal for Ca(2+) release channel

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Role of the proposed pore-forming segment of the Ca2+ release channel (ryanodine receptor) in ryanodine interaction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Functional characterization of mutants in the predicted pore region of the rabbit cardiac muscle Ca(2+) release channel (ryanodine receptor isoform 2).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Evidence for a role of the lumenal M3-M4 loop in skeletal muscle Ca(2+) release channel (ryanodine receptor) activity and conductance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Molecular identification of the ryanodine receptor pore-forming segment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ryanodine receptor interaction with the SNARE-associated protein snapin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Identification of the domain recognized by anti-(ryanodine receptor) antibodies which affect Ca(2+)-induced Ca2+ release

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ryanodine receptor mutations in malignant hyperthermia and central core disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Abnormal ryanodine receptor function in heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Luminal loop of the ryanodine receptor: a pore-forming segment?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Cardiac ryanodine receptor phosphorylation: target sites and functional consequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Calstabin deficiency, ryanodine receptors, and sudden cardiac death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Intracellular calcium release and cardiac disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

A guide for the perplexed: towards an understanding of the molecular basis of heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Defective cardiac ryanodine receptor regulation during atrial fibrillation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Altered interaction of FKBP12.6 with ryanodine receptor as a cause of abnormal Ca(2+) release in heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

"Ryanogate": who leaked the calcium?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Protein phosphatases decrease sarcoplasmic reticulum calcium content by stimulating calcium release in cardiac myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Maximum phosphorylation of the cardiac ryanodine receptor at serine-2809 by protein kinase a produces unique modifications to channel gating and conductance not observed at lower levels of phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Stoichiometric phosphorylation of cardiac ryanodine receptor on serine 2809 by calmodulin-dependent kinase II and protein kinase A.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Calmodulin kinase inhibition prevents development of the arrhythmogenic transient inward current

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Calmodulin kinase II inhibition protects against structural heart disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

The mAKAP signaling complex: integration of cAMP, calcium, and MAP kinase signaling pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Protein kinase A phosphorylation at serine-2808 of the cardiac Ca2+-release channel (ryanodine receptor) does not dissociate 12.6-kDa FK506-binding protein (FKBP12.6).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Characterization of Recombinant Skeletal Muscle (Ser-2843) and Cardiac Muscle (Ser-2809) Ryanodine Receptor Phosphorylation Mutants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractility

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Regulation of cardiac muscle Ca2+ release channel by sarcoplasmic reticulum lumenal Ca2+

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Evidence for Ca(2+) activation and inactivation sites on the luminal side of the cardiac ryanodine receptor complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Regulation of ryanodine receptors by calsequestrin: effect of high luminal Ca2+ and phosphorylation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

T-tubule function in mammalian cardiac myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Orphaned ryanodine receptors in the failing heart.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

A cardiac arrhythmia syndrome caused by loss of ankyrin-B function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ryanodine receptor-ankyrin interaction regulates internal Ca2+ release in mouse T-lymphoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

cAMP-induced Cytoskeleton Rearrangement Increases Calcium Transients through the Enhancement of Capacitative Calcium Entry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Conformational activation of Ca2+ entry by depolarization of skeletal myotubes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ryanodine receptor type 1 (RyR1) mutations C4958S and C4961S reveal excitation-coupled calcium entry (ECCE) is independent of sarcoplasmic reticulum store depletion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Action potential refractory period in ureter smooth muscle is set by Ca sparks and BK channels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Enhanced basal activity of a cardiac Ca2+ release channel (ryanodine receptor) mutant associated with ventricular tachycardia and sudden death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Cellular basis of triggered arrhythmias in heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Coupled calcium release channels and their regulation by luminal and cytosolic ions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Light at the end of the Ca(2+)-release channel tunnel: structures and mechanisms involved in ion translocation in ryanodine receptor channels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Integrative analysis of calcium cycling in cardiac muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Integrative analysis of calcium signalling in cardiac muscle.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Three-dimensional architecture of the calcium channel/foot structure of sarcoplasmic reticulum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Structure of Ca2+ release channel at 14 A resolution

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Arrhythmogenic mutation-linked defects in ryanodine receptor autoregulation reveal a novel mechanism of Ca2+ release channel dysfunction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Peptide probe study of the critical regulatory domain of the cardiac ryanodine receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Unzipping RyR2 in adult cardiomyocytes: getting closer to mechanisms of inherited ventricular arrhythmias?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Molecular architecture of membranes involved in excitation-contraction coupling of cardiac muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Conformational spread: the propagation of allosteric states in large multiprotein complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

The Ca 2+ leak paradox and rogue ryanodine receptors: SR Ca 2+ efflux theory and practice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Intrinsic lattice formation by the ryanodine receptor calcium-release channel

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Coupled gating between cardiac calcium release channels (ryanodine receptors).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Coupled gating between individual skeletal muscle Ca2+ release channels (ryanodine receptors)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Physical coupling between ryanodine receptor-calcium release channels.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Location of divergent region 2 on the three-dimensional structure of cardiac muscle ryanodine receptor/calcium release channel.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Three-dimensional visualization of FKBP12.6 binding to an open conformation of cardiac ryanodine receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ryanodine receptor oligomeric interaction: identification of a putative binding region.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Effect of Calcium on Acetylstrophanthidin-Induced Transient Depolarizations in Canine Purkinje Tissue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Mechanisms of digitalis toxicity. Effects of ouabain on phase four of canine Purkinje fiber transmembrane potentials

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Role of ryanodine receptor mutations in cardiac pathology: more questions than answers?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Effect of ryanodine on ventricular fibrillation induced by myocardial ischaemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Intracellular calcium transients and arrhythmia in isolated heart cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Effects of ryanodine on inotropic and arrhythmogenic actions of cardiotonic steroids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Calcium oscillations in digitalis-induced ventricular fibrillation: pathogenetic role and metabolic consequences in isolated ferret hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Role of calcium and the calcium channel in the initiation and maintenance of ventricular fibrillation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Enhanced Ca 2+ Current and Decreased Ca 2+ Efflux Restore Sarcoplasmic Reticulum Ca 2+ Content After Depletion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Calcium channel antagonism reduces exercise-induced ventricular arrhythmias in catecholaminergic polymorphic ventricular tachycardia patients with RyR2 mutations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Catecholaminergic polymorphic ventricular tachycardia: electrocardiographic characteristics and optimal therapeutic strategies to prevent sudden death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Cellular mechanisms underlying the development of catecholaminergic ventricular tachycardia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Cellular mechanism of calcium-mediated triggered activity in the heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Familial polymorphic ventricular tachycardia--intracellular calcium channel disorder

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Novel therapeutic approaches for heart failure by normalizing calcium cycling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Myocardial calcium signalling and arrhythmia pathogenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Reducing ryanodine receptor open probability as a means to abolish spontaneous Ca2+ release and increase Ca2+ transient amplitude in adult ventricular myocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Effects of a novel cardioprotective drug, JTV-519, on membrane currents of guinea pig ventricular myocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Inhibitory effects of JTV-519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea-pig hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Anti-ischemic effect of a novel cardioprotective agent, JTV519, is mediated through specific activation of delta-isoform of protein kinase C in rat ventricular myocardium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

The cardioprotective effects of a new 1,4-benzothiazepine derivative, JTV519, on ischemia/reperfusion-induced Ca2+ overload in isolated rat hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

New cardioprotective agent K201 is natriuretic and glomerular filtration rate enhancing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Sealing the leak, healing the heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular tachycardia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Not all sudden death is the same

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Can novel therapies for arrhythmias caused by spontaneous sarcoplasmic reticulum Ca2+ release be developed using mouse models?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Inherited arrhythmogenic diseases: the complexity beyond monogenic disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Abnormalities of calcium cycling in the hypertrophied and failing heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Ryanodine receptors/calcium release channels in heart failure and sudden cardiac death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Propranolol prevents the development of heart failure by restoring FKBP12.6-mediated stabilization of ryanodine receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

beta-adrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

Mutations to Gly2370, Gly2373 or Gly2375 in malignant hyperthermia domain 2 decrease caffeine and cresol sensitivity of the rabbit skeletal-muscle Ca2+-release channel (ryanodine receptor isoform 1)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2006.08.115

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.YJMCC.2006.08.115

1 reference

release_7ddiznhk3neo3nqta7g4t73v2q

15 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7ddiznhk3neo3nqta7g4t73v2q

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference