Novel therapeutic approaches for heart failure by normalizing calcium cycling (Q35825873)

10 August 2017

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title

Novel therapeutic approaches for heart failure by normalizing calcium cycling (English)

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10 August 2017

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1

Xander H T Wehrens

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10 August 2017

Andrew R Marks

2

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10 August 2017

1 July 2004

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Nature Reviews Drug Discovery

10 August 2017

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10 August 2017

3

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10 August 2017

7

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10 August 2017

565-573

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https://scigraph.springernature.com/pub.10.1038/nrd1440

10 August 2017

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cites work

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Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium.

31 March 2020

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Cardiac excitation-contraction coupling

31 March 2020

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Ryanodine receptor calcium release channels

31 March 2020

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Altered function and regulation of cardiac ryanodine receptors in cardiac disease

31 March 2020

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T-type Ca2+ current as a trigger for Ca2+ release from the sarcoplasmic reticulum in guinea-pig ventricular myocytes

31 March 2020

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Low efficiency of Ca2+ entry through the Na(+)-Ca2+ exchanger as trigger for Ca2+ release from the sarcoplasmic reticulum. A comparison between L-type Ca2+ current and reverse-mode Na(+)-Ca2+ exchange

31 March 2020

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Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum

31 March 2020

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The relative phospholamban and SERCA2 ratio: a critical determinant of myocardial contractility

31 March 2020

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Relaxation of rabbit ventricular muscle by Na-Ca exchange and sarcoplasmic reticulum calcium pump. Ryanodine and voltage sensitivity

31 March 2020

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PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

31 March 2020

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Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor

31 March 2020

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PKC-alpha regulates cardiac contractility and propensity toward heart failure

31 March 2020

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Seven-transmembrane-spanning receptors and heart function

31 March 2020

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Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure

31 March 2020

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Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels

31 March 2020

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Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban

31 March 2020

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Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release

31 March 2020

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Phosphorylation of phospholamban in the intact heart. A study on the physiological role of the Ca(2+)-calmodulin-dependent protein kinase system

31 March 2020

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Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes

31 March 2020

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Dual site phospholamban phosphorylation and its physiological relevance in the heart

31 March 2020

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Protein kinase C isozymes and the regulation of diverse cell responses

31 March 2020

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Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1

31 March 2020

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The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis

31 March 2020

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Specific association of calmodulin-dependent protein kinase and related substrates with the junctional sarcoplasmic reticulum of skeletal muscle

31 March 2020

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Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers

31 March 2020

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Calcium/calmodulin-dependent protein kinase IIdelta associates with the ryanodine receptor complex and regulates channel function in rabbit heart.

31 March 2020

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Association of Sorcin With the Cardiac Ryanodine Receptor

31 March 2020

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Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane

31 March 2020

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Triad formation: organization and function of the sarcoplasmic reticulum calcium release channel and triadin in normal and dysgenic muscle in vitro.

31 March 2020

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Identification of a region of calsequestrin that binds to the junctional face membrane of sarcoplasmic reticulum

31 March 2020

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Abnormal calcium signaling and sudden cardiac death associated with mutation of calsequestrin

31 March 2020

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FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

31 March 2020

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Coupled gating between individual skeletal muscle Ca2+ release channels (ryanodine receptors)

31 March 2020

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FKBP12 binding modulates ryanodine receptor channel gating

31 March 2020

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Phosphorylation modulates the function of the calcium release channel of sarcoplasmic reticulum from cardiac muscle

31 March 2020

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Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation

31 March 2020

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Gating of the skeletal calcium release channel by ATP is inhibited by protein phosphatase 1 but not by Mg2+

31 March 2020

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Protein phosphatases decrease sarcoplasmic reticulum calcium content by stimulating calcium release in cardiac myocytes

31 March 2020

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Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure

31 March 2020

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Altered diastolic [Ca2+]i handling in human ventricular myocytes from patients with terminal heart failure

31 March 2020

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The contributions of sympathetic tone and the renin-angiotensin system to severe chronic congestive heart failure: response to specific inhibitors (prazosin and captopril).

31 March 2020

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Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure

31 March 2020

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Reduced beta 1 receptor messenger RNA abundance in the failing human heart

31 March 2020

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Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

31 March 2020

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Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

31 March 2020

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L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices

31 March 2020

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Protein kinase A hyperphosphorylation increases basal current but decreases beta-adrenergic responsiveness of the sarcolemmal Na+-Ca2+ exchanger in failing pig myocytes

31 March 2020

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The sarcoplasmic reticulum and the Na+/Ca2+ exchanger both contribute to the Ca2+ transient of failing human ventricular myocytes

31 March 2020

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Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents

31 March 2020

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Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol

31 March 2020

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Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure

31 March 2020

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Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)

31 March 2020

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The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group

31 March 2020

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Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure.

31 March 2020

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beta-adrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure

31 March 2020

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Propranolol prevents the development of heart failure by restoring FKBP12.6-mediated stabilization of ryanodine receptor

31 March 2020

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CHF-1024, a DA2/alpha2 agonist, blunts norepinephrine excretion and cardiac fibrosis in pressure overload.

31 March 2020

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Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase

31 March 2020

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Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure

31 March 2020

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Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

31 March 2020

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Effect of metoprolol CR/XL on exercise tolerance in chronic heart failure - a substudy to the MERIT-HF trial.

31 March 2020

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Role of beta-adrenergic receptor downregulation in the peak exercise response in patients with heart failure due to idiopathic dilated cardiomyopathy

31 March 2020

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Sealing the leak, healing the heart

31 March 2020

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Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

31 March 2020

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A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure

31 March 2020

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FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure

31 March 2020

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Modulation of ventricular function through gene transfer in vivo

31 March 2020

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Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy

31 March 2020

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Sarcoplasmic reticulum Ca(2+)-ATPase overexpression by adenovirus mediated gene transfer and in transgenic mice

31 March 2020

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Stimulation of sarcoplasmic reticulum Ca(2+)-ATPase by gingerol analogues

31 March 2020

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Mechanism of action of sarcoplasmic reticulum calcium-uptake activators--discrimination between sarco(endo)plasmic reticulum Ca2+ ATPase and phospholamban interaction

31 March 2020

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31 March 2020

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Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery

31 March 2020

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Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats.

31 March 2020

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Targeting phospholamban by gene transfer in human heart failure

31 March 2020

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Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

31 March 2020

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Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

31 March 2020

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Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction

31 March 2020

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Protein Kinase Cα Negatively Regulates Systolic and Diastolic Function in Pathological Hypertrophy

31 March 2020

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Kinases as therapeutic targets for heart failure

31 March 2020

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Contribution of reverse-mode sodium-calcium exchange to contractions in failing human left ventricular myocytes.

31 March 2020

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A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1

31 March 2020

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Enhanced Ca(2+)-activated Na(+)-Ca(2+) exchange activity in canine pacing-induced heart failure

31 March 2020

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Cardiac Na(+)-Ca(2+) exchange: molecular and pharmacological aspects

31 March 2020

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Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractility

31 March 2020

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Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure

31 March 2020

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Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility

31 March 2020

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Differing cardioprotective efficacy of the Na+/Ca2+ exchanger inhibitors SEA0400 and KB-R7943.

31 March 2020

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Novel insights in the congenital long QT syndrome

31 March 2020

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Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular tachycardia

31 March 2020

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Catecholaminergic polymorphic ventricular tachycardia in children. A 7-year follow-up of 21 patients

31 March 2020

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Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia

31 March 2020

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Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia

31 March 2020

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Familial polymorphic ventricular arrhythmias: a quarter century of successful medical treatment based on serial exercise-pharmacologic testing

31 March 2020

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Arrhythmic disorder mapped to chromosome 1q42-q43 causes malignant polymorphic ventricular tachycardia in structurally normal hearts

31 March 2020

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Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes

31 March 2020

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Enhanced basal activity of a cardiac Ca2+ release channel (ryanodine receptor) mutant associated with ventricular tachycardia and sudden death

31 March 2020

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Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor

31 March 2020

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Effect of a novel cardioprotective agent, JTV-519, on metabolism, contraction and relaxation in the ischemia-reperfused rabbit heart

31 March 2020

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The cardioprotective effects of a new 1,4-benzothiazepine derivative, JTV519, on ischemia/reperfusion-induced Ca2+ overload in isolated rat hearts

31 March 2020

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Anti-ischemic effect of a novel cardioprotective agent, JTV519, is mediated through specific activation of delta-isoform of protein kinase C in rat ventricular myocardium

31 March 2020

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JTV-519, a novel cardioprotective agent, improves the contractile recovery after ischaemia-reperfusion in coronary perfused guinea-pig ventricular muscles

31 March 2020

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Inhibitory effects of JTV-519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea-pig hearts

31 March 2020

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Antiarrhythmic effects of JTV-519, a novel cardioprotective drug, on atrial fibrillation/flutter in a canine sterile pericarditis model

31 March 2020

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Sarcoplasmic Reticulum Ca2+ Release Causes Myocyte Depolarization : Underlying Mechanism and Threshold for Triggered Action Potentials

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1440

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PubMed ID

15232578

Dimensions Publication ID

10 August 2017

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1 reference

PubMed ID

15232578