APC regulator of WNT signaling pathway (Q356062)

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mammalian protein found in Homo sapiens
  • truncated adenomatosis polyposis coli
  • protein phosphatase 1, regulatory subunit 46
  • adenomatous polyposis coli protein
  • APC, WNT signaling pathway regulator
  • epididymis secretory sperm binding protein
  • WNT signaling pathway regulator
  • adenomatosis polyposis coli tumor suppressor
  • deleted in polyposis 2.5
  • APC
  • adenomatous polyposis coli (APC)
edit
Language Label Description Also known as
English
APC regulator of WNT signaling pathway
mammalian protein found in Homo sapiens
  • truncated adenomatosis polyposis coli
  • protein phosphatase 1, regulatory subunit 46
  • adenomatous polyposis coli protein
  • APC, WNT signaling pathway regulator
  • epididymis secretory sperm binding protein
  • WNT signaling pathway regulator
  • adenomatosis polyposis coli tumor suppressor
  • deleted in polyposis 2.5
  • APC
  • adenomatous polyposis coli (APC)

Statements

part of
molecular function
protein binding
determination method
IPI
43 references
retrieved
8 April 2019
stated in
Asef, a link between the tumor suppressor APC and G-protein signaling
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Amer2 protein is a novel negative regulator of Wnt/β-catenin signaling involved in neuroectodermal patterning
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
An EB1-binding motif acts as a microtubule tip localization signal
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
A role for the Adenomatous Polyposis Coli protein in chromosome segregation
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Proteome-wide analysis of phospho-regulated PDZ domain interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Modeling of a human circadian mutation yields insights into clock regulation by PER2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-β-catenin signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
An EB1-binding motif acts as a microtubule tip localization signal
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Asef, a link between the tumor suppressor APC and G-protein signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
beta-catenin binding
determination method
IEA
IPI
6 references
retrieved
24 April 2018
stated in
Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
24 April 2018
stated in
Regulation and function of the interaction between the APC tumour suppressor protein and EB1
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
24 April 2018
stated in
The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
24 April 2018
stated in
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
24 April 2018
stated in
The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054
determination method
IEA
beta-catenin binding
determination method
IDA
IEA
IPI
7 references
retrieved
5 June 2018
stated in
Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
5 June 2018
stated in
Regulation and function of the interaction between the APC tumour suppressor protein and EB1
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
5 June 2018
stated in
The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
5 June 2018
stated in
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
5 June 2018
stated in
The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
5 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054
determination method
IEA
retrieved
5 June 2018
stated in
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054
determination method
IDA
beta-catenin binding
determination method
IBA
IDA
IEA
IPI
8 references
retrieved
8 April 2019
stated in
Regulation and function of the interaction between the APC tumour suppressor protein and EB1
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IPI
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IEA
retrieved
8 April 2019
stated in
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IBA
cell component
beta-catenin destruction complex
determination method
IBA
IDA
5 references
retrieved
8 April 2019
stated in
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IDA
retrieved
8 April 2019
stated in
The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IDA
retrieved
8 April 2019
stated in
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IDA
retrieved
8 April 2019
stated in
The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IBA
biological process
negative regulation of canonical Wnt signaling pathway
determination method
IBA
IC
IGI
NAS
5 references
retrieved
8 April 2019
stated in
Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
NAS
retrieved
8 April 2019
stated in
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IGI
retrieved
8 April 2019
stated in
Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IGI
retrieved
8 April 2019
stated in
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
GOA
curator
UniProt
UniProt protein ID
P25054
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IC
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054
determination method
IBA
Gene Atlas image
PBB GE APC 216933 x at fs.png
732 × 530; 12 KB
0 references
Commons category
Adenomatous polyposis coli protein
0 references

Identifiers

PDB structure ID
 
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q356062&oldid=2022900843"