Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation (Q24319918)

GOA release 2020-03-11

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6

Tommy Martinsson

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author name string

Henrik Fagman

1

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Fredrik Larsson

2

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Yvonne Arvidsson

3

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Johan Meuller

4

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Margareta Nordling

5

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Karen Helmbrecht

7

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Georg Brabant

8

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Mikael Nilsson

APC senses cell-cell contacts and moves to the nucleus upon their disruption.

9

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language of work or name

English

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publication date

4 September 2003

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published in

Oncogene

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volume

22

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page(s)

6013-22

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issue

38

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cites work

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Nuclear export of human beta-catenin can occur independent of CRM1 and the adenomatous polyposis coli tumor suppressor

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ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A.

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Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein

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E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

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The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells

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Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

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The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

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Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein.

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APC mutation analysis by chemical cleavage of mismatch and a protein truncation assay in familial adenomatous polyposis

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APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"

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The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells

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The APC gene product in normal and tumor cells

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Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein

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Joining the cell survival squad: an emerging role for protein kinase CK2.

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The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase

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The subcellular destinations of APC proteins

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Genetic alterations in thyroid carcinoma associated with familial adenomatous polyposis: clinical implications and suggestions for early detection

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The APC protein binds to A/T rich DNA sequences

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Mutations in the APC tumour suppressor gene cause chromosomal instability

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APC, signal transduction and genetic instability in colorectal cancer

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A Drosophila APC tumour suppressor homologue functions in cellular adhesion.

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Identification of c-MYC as a target of the APC pathway

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Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover

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The ins and outs of APC and beta-catenin nuclear transport

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The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase

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A role for the Adenomatous Polyposis Coli protein in chromosome segregation

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Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm

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APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export

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The APC tumour suppressor has a nuclear export function.

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Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A

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CRM1- and Ran-independent nuclear export of beta-catenin.

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Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein

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