Sex is a major determinant of CYP3A4 expression in human liver (Q34265530)

1 August 2017

Sex is a major determinant of CYP3A4 expression in human liver. (English)

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1 August 2017

5

Peter Neuhaus

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1 August 2017

8

Ulrich M Zanger

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1 August 2017

Renzo Wolbold

1

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1 August 2017

Kathrin Klein

2

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1 August 2017

Oliver Burk

3

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1 August 2017

Andreas K Nüssler

4

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1 August 2017

Michel Eichelbaum

6

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1 August 2017

Matthias Schwab

7

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1 August 2017

language of work or name

English

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publication date

1 October 2003

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1 August 2017

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1 August 2017

38

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1 August 2017

4

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1 August 2017

978-988

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Intersubject and dose-related variability after intravenous administration of erythromycin.

1 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

Alterations in prednisolone disposition as a result of time of administration, gender and dose

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

Cytochrome P-450 3A4: regulation and role in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Pharmacogenomics: translating functional genomics into rational therapeutics

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https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

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https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Identification and functional characterization of eight CYP3A4 protein variants

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https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

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https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Regulation of cyp3a gene transcription by the pregnane x receptor

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https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Gender effects in pharmacokinetics and pharmacodynamics

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https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

How important are gender differences in pharmacokinetics?

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https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Demographic factors affecting the pharmacokinetics of cyclosporine estimated by radioimmunoassay

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Effect of age and gender on tirilazad pharmacokinetics in humans

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Chronopharmacology of intravenous and oral modified release verapamil.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Race and sex influence clearance of nifedipine: results of a population study

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Diazepam disposition determinants.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Influence of age on the pharmacokinetics of alfentanil. Gender dependence.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

A wide interindividual variability of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy Japanese subjects in near basal condition

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Effect of age and gender on the activity of human hepatic CYP3A

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https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Gender difference in ifosfamide metabolism by human liver microsomes

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Effects of age and gender on in vitro properties of human liver microsomal monooxygenases

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https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Genetic polymorphisms of the human MDR1 drug transporter

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Mdr1 limits CYP3A metabolism in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

A rapid and simple method for sex identification by heteroduplex analysis, using denaturing high-performance liquid chromatography (DHPLC).

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography-mass spectrometry

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Identification of P450 enzymes involved in metabolism of verapamil in humans

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https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

The genetic determinants of the CYP3A5 polymorphism

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Effects of endogenous steroids on CYP3A4-mediated drug metabolism by human liver microsomes

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Quantification of 3-month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

STAT5 signaling in sexually dimorphic gene expression and growth patterns

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Sex-dependent metabolism of xenobiotics.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Basal plasma growth hormone levels in man: new evidence for rhythmicity of growth hormone secretion.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Involvement of STAT5 (signal transducer and activator of transcription 5) and HNF-4 (hepatocyte nuclear factor 4) in the transcriptional control of the hnf6 gene by growth hormone

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Clinically significant pharmacokinetic drug interactions with carbamazepine. An update

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Women in clinical trials of new drugs. A change in Food and Drug Administration policy. The Working Group on Women in Clinical Trials

1 reference

https://api.crossref.org/works/10.1002%2FHEP.1840380424

7 January 2021

Identifiers

DOI

10.1002/HEP.1840380424

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1 August 2017

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