The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4 (Q28201907)

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16 December 2019

title

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4 (English)

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16 December 2019

2

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Stephen A. Duncan

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16 December 2019

author name string

Rommel G Tirona

1

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16 December 2019

Brenda F Leake

3

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Lu-Bin Lan

4

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16 December 2019

Cynthia Brimer Cline

5

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Vishal Lamba

6

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16 December 2019

Fereshteh Parviz

7

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Yusuke Inoue

9

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Frank J Gonzalez

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Erin G Schuetz

11

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Richard B Kim

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language of work or name

English

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publication date

6 January 2003

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16 December 2019

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volume

9

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issue

2

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16 December 2019

page(s)

220-224

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In vitro and in vivo drug interactions involving human CYP3A.

16 December 2019

cites work

1 reference

7 January 2021

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

1 reference

7 January 2021

Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.

1 reference

7 January 2021

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

1 reference

7 January 2021

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

1 reference

7 January 2021

Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents

1 reference

7 January 2021

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

1 reference

7 January 2021

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

1 reference

7 January 2021

Generation of a conditionally null allele ofhnf4?

1 reference

7 January 2021

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

1 reference

7 January 2021

A transcriptional hierarchy involved in mammalian cell-type specification

1 reference

7 January 2021

Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome

1 reference

7 January 2021

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily

1 reference

7 January 2021

Hepatocyte nuclear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AI regulatory protein I and v-ErbA-related protein 3.

1 reference

7 January 2021

Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression

1 reference

7 January 2021

Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.

1 reference

7 January 2021

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

1 reference

7 January 2021

Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM815

2 references

Consolidated OpenCitations Corpus – April 2017

1720975

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1720975

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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1720975