Sin: good or bad? A T lymphocyte perspective (Q34187562)

31 July 2017

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title

Sin: good or bad? A T lymphocyte perspective (English)

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31 July 2017

Konstantina Alexandropoulos

1

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31 July 2017

Laura T Donlin

2

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31 July 2017

Luzhou Xing

3

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31 July 2017

Adam G Regelmann

4

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31 July 2017

1 April 2003

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31 July 2017

Immunological Reviews

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31 July 2017

192

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31 July 2017

181-195

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Signal transduction: hanging on a scaffold.

31 July 2017

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

SH2/SH3 signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

The PTB domain: a new protein module implicated in signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Peptide recognition by PTB and PDZ domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Characterization of a novel protein-binding module--the WW domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

The PH domain: a common piece in the structural patchwork of signalling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

SH2 domains recognize specific phosphopeptide sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Recognition of unique carboxyl-terminal motifs by distinct PDZ domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Scaffolds, adaptors and linkers of TCR signaling: theory and practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Adapters in lymphocyte signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Intracellular adapter molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Integration of T cell receptor-dependent signaling pathways by adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Lymphocytes with a complex: adapter proteins in antigen receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Signaling scaffolds in immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

The role of Grb2-associated proteins in T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Essential role of LAT in T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Differential role of SLP-76 domains in T cell development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Coupling of the TCR to integrin activation by Slap-130/Fyb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Cbl: many adaptations to regulate protein tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Cbl-b regulates the CD28 dependence of T-cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Integrin signalling: a new Cas(t) of characters enters the stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Beta 1-integrin-mediated cell signaling in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Identification of an Efs isoform that lacks the SH3 domain and chromosomal mapping of human Efs

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Adhesion through the interaction of lymphocyte function-associated antigen-1 with intracellular adhesion molecule-1 induces tyrosine phosphorylation of p130cas and its association with c-CrkII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Src kinase plays an essential role in integrin-mediated tyrosine phosphorylation of Crk-associated substrate p130Cas

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Signaling through focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Activation of Wiskott-Aldrich syndrome protein and its association with other proteins by stromal cell-derived factor-1alpha is associated with cell migration in a T-lymphocyte line

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Fyn and Lck tyrosine kinases regulate tyrosine phosphorylation of p105CasL, a member of the p130Cas docking protein family, in T-cell receptor-mediated signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Crystal structure of the Src family tyrosine kinase Hck

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Profound block in thymocyte development in mice lacking p56lck

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Combinatorial effect of T-cell receptor ligation and CD45 isoform expression on the signaling contribution of the small GTPases Ras and Rap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Requirement for the SLP-76 adaptor GADS in T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Identification of a ten-amino acid proline-rich SH3 binding site

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Adapters in lymphocyte signaling

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Differential requirement for SLP-76 domains in T cell development and function

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Defective thymocyte maturation by transgenic expression of a truncated form of the T lymphocyte adapter molecule and Fyn substrate, Sin.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Ligation of the T cell antigen receptor induces tyrosine phosphorylation of p105CasL, a member of the p130Cas-related docking protein family, and its subsequent binding to the Src homology 2 domain of c-Crk

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Proline-rich sequences that bind to Src homology 3 domains with individual specificities

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Focal adhesion kinase in integrin-mediated signaling

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00021.X

7 January 2021

10.1034/J.1600-065X.2003.00021.X

Identifiers

DOI

1 reference

31 July 2017

1 reference