Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ (Q28115380)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19806195%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ (English)

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19806195%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

main subject

DNA polymerase lambda

1 reference

GOA release 2020-03-11

DNA biosynthetic process

1 reference

GOA release 2020-03-11

author

Tomas Kirchhoff

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19806195%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Thomas A Kunkel

11

1 reference

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9 February 2020

author name string

Gloria Terrados

1

2 references

3 January 2017

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9 February 2020

Jean-Pascal Capp

2

2 references

3 January 2017

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9 February 2020

Yvan Canitrot

3

2 references

3 January 2017

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9 February 2020

Miguel García-Díaz

4

2 references

3 January 2017

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9 February 2020

Katarzyna Bebenek

5

2 references

3 January 2017

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9 February 2020

Alberto Villanueva

7

2 references

3 January 2017

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9 February 2020

François Boudsocq

8

2 references

3 January 2017

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9 February 2020

Valérie Bergoglio

9

2 references

3 January 2017

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9 February 2020

Christophe Cazaux

10

2 references

3 January 2017

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9 February 2020

Jean-Sébastien Hoffmann

12

2 references

3 January 2017

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9 February 2020

Luis Blanco

13

2 references

3 January 2017

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9 February 2020

language of work or name

English

0 references

publication date

6 October 2009

2 references

3 January 2017

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9 February 2020

2 references

3 January 2017

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9 February 2020

volume

4

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3 January 2017

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9 February 2020

issue

10

2 references

3 January 2017

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9 February 2020

page(s)

e7290

2 references

3 January 2017

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Creative Commons Attribution 4.0 International

9 February 2020

copyright license

start time

6 October 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs

20 March 2017

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The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

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20 March 2017

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20 March 2017

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A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining

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Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis

20 March 2017

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Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair

20 March 2017

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DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts

20 March 2017

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A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology

20 March 2017

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Polymorphisms in the human DNA polymerase beta gene

20 March 2017

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DNA polymerase beta mutations in human colorectal cancer

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DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis

20 March 2017

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

20 March 2017

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A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins

7 April 2017

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From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

7 April 2017

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Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation

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DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair

29 September 2017

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A closed conformation for the Pol lambda catalytic cycle.

29 September 2017

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A biochemically defined system for mammalian nonhomologous DNA end joining

29 September 2017

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Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells.

29 September 2017

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A DNA polymerase beta mutant from colon cancer cells induces mutations

29 September 2017

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Functions of eukaryotic DNA polymerases

29 September 2017

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Considering the cancer consequences of altered DNA polymerase function

29 September 2017

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Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesis

29 September 2017

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29 September 2017

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Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.

29 September 2017

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Identification and characterization of human DNA polymerase beta 2, a DNA polymerase beta -related enzyme

29 September 2017

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The E249K mutator mutant of DNA polymerase beta extends mispaired termini

29 September 2017

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The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells

29 September 2017

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The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts

2 June 2018

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2 June 2018

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DNA polymerase lambda, a novel DNA repair enzyme in human cells.

2 June 2018

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10.1371/JOURNAL.PONE.0007290

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19806195%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

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1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19806195%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

2 references

3 January 2017