Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways (Q24321504)

Mitogen-activated protein kinase kinase kinase 10

GOA release 2020-03-11

1 reference

negative regulation of transcription, DNA-templated

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

6

Carme Gallego

0 references

Neus Pedraza

object named as

Neus Pedraza

1

0 references

Mario Encinas

object named as

Mario Encinas

4

0 references

Martí Aldea

object named as

Martí Aldea

5

0 references

author name string

Marta Rafel

2

0 references

Isis Navarro

Journal of Biological Chemistry

3

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language of work or name

English

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publication date

20 November 2009

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published in

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volume

284

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issue

47

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page(s)

32980-8

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on focus list of Wikimedia project

ScienceSource

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cites work

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Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity

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MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase

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E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription

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27 September 2017

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27 September 2017

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The E2A gene product contains two separable and functionally distinct transcription activation domains

27 September 2017

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c-jun inhibits insulin control element-mediated transcription by affecting the transactivation potential of the E2A gene products

27 September 2017

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Programmed cell death in neurons: focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neurons.

27 September 2017

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Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease

27 September 2017

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Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

30 May 2018

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Activated JNK phosphorylates the c-terminal domain of MLK2 that is required for MLK2-induced apoptosis

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.038729

Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain

21 January 2018

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Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons.

21 January 2018

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Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family

29 November 2018

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12 December 2020

Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway

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12 December 2020

Expression of mixed lineage kinase 2 in germ cells of the testis

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12 December 2020

Mixed-lineage kinase inhibitors require the activation of Trk receptors to maintain long-term neuronal trophism and survival

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12 December 2020

Expression and function of mixed lineage kinases in dendritic cells

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12 December 2020

Accelerated Notch-dependent degradation of E47 proteins in aged B cell precursors is associated with increased ERK MAPK activation

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12 December 2020