Transcription factor 3 (Q21111604)

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mammalian protein found in Homo sapiens
  • negative vitamin D response element-binding protein
  • Immunoglobulin enhancer-binding factor E12/E47
  • TCF3
  • bHLHb21
  • transcription factor ITF-1
  • VDR interacting repressor
  • immunoglobulin transcription factor 1
  • transcription factor E2-alpha
  • transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
  • helix-loop-helix protein HE47
  • vitamin D receptor-interacting repressor
  • kappa-E2-binding factor
  • NOL1-TCF3 fusion
  • class B basic helix-loop-helix protein 21
  • TCF-3
  • transcription factor 3 variant 3
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Language Label Description Also known as
English
Transcription factor 3
mammalian protein found in Homo sapiens
  • negative vitamin D response element-binding protein
  • Immunoglobulin enhancer-binding factor E12/E47
  • TCF3
  • bHLHb21
  • transcription factor ITF-1
  • VDR interacting repressor
  • immunoglobulin transcription factor 1
  • transcription factor E2-alpha
  • transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
  • helix-loop-helix protein HE47
  • vitamin D receptor-interacting repressor
  • kappa-E2-binding factor
  • NOL1-TCF3 fusion
  • class B basic helix-loop-helix protein 21
  • TCF-3
  • transcription factor 3 variant 3

Statements

molecular function
DNA-binding transcription factor activity
determination method
NAS
IDA
6 references
retrieved
27 March 2018
stated in
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
NAS
retrieved
27 March 2018
stated in
Regulation of E2A activities by histone acetyltransferases in B lymphocyte development
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
27 March 2018
stated in
Promotion of cell cycle progression by basic helix-loop-helix E2A
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
27 March 2018
stated in
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
27 March 2018
stated in
Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
27 March 2018
stated in
Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IDA
protein binding
determination method
IPI
10 references
retrieved
8 April 2019
stated in
Notch signaling induces rapid degradation of achaete-scute homolog 1.
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IPI
retrieved
8 April 2019
stated in
Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IPI
retrieved
8 April 2019
stated in
Mutations affecting the BHLHA9 DNA-binding domain cause MSSD, mesoaxial synostotic syndactyly with phalangeal reduction, Malik-Percin type
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IPI
retrieved
8 April 2019
stated in
HEB and E2A function as SMAD/FOXH1 cofactors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IPI
retrieved
8 April 2019
stated in
Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IPI
retrieved
8 April 2019
stated in
Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IPI
retrieved
8 April 2019
stated in
SCL binds the human homologue of DRG in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IPI
retrieved
8 April 2019
stated in
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IPI
retrieved
8 April 2019
stated in
HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IPI
protein heterodimerization activity
determination method
NAS
IDA
IPI
5 references
retrieved
27 March 2018
stated in
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
NAS
retrieved
27 March 2018
stated in
Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IPI
retrieved
27 March 2018
stated in
Regulation of scleraxis function by interaction with the bHLH protein E47
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
27 March 2018
stated in
Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
27 March 2018
stated in
LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IDA
protein heterodimerization activity
determination method
IBA
IDA
IPI
NAS
6 references
retrieved
8 April 2019
stated in
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
NAS
retrieved
8 April 2019
stated in
Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of scleraxis function by interaction with the bHLH protein E47
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
8 April 2019
stated in
Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
8 April 2019
stated in
LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IBA
cell component
nucleus
determination method
NAS
IDA
IEA
8 references
retrieved
27 March 2018
stated in
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
NAS
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IEA
retrieved
27 March 2018
stated in
Regulation of scleraxis function by interaction with the bHLH protein E47
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
27 March 2018
stated in
Regulation of E2A activities by histone acetyltransferases in B lymphocyte development
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
27 March 2018
stated in
Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 suppresses differentiation by negative regulation of transcription
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
27 March 2018
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
27 March 2018
stated in
Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
27 March 2018
stated in
HEB and E2A function as SMAD/FOXH1 cofactors
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15923&geneProductId=UniProtKB:P15923
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
NAS
7 references
retrieved
8 April 2019
stated in
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IEA
retrieved
8 April 2019
stated in
Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 suppresses differentiation by negative regulation of transcription
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
8 April 2019
stated in
Regulation of scleraxis function by interaction with the bHLH protein E47
GOA
curator
UniProt
UniProt protein ID
P15923
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
8 April 2019
stated in
HEB and E2A function as SMAD/FOXH1 cofactors
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15923
determination method
IBA
biological process

Identifiers

RefSeq protein ID
Ensembl protein ID
 
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