The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3 (Q24320222)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21827945%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21827945%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

0 references

0 references

Apoptotic peptidase activating factor 1

1 reference

GOA release 2020-03-11

Caspase 9

1 reference

GOA release 2020-03-11

1 reference

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21827945%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

5

Steven J Ludtke

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21827945%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

3

John M Asara

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21827945%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

4

John E Heuser

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21827945%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

author name string

Shujun Yuan

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21827945%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Xinchao Yu

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21827945%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

language of work or name

English

0 references

publication date

1 August 2011

1 reference

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9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21827945%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

19

1 reference

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9 February 2020

page(s)

1084-1096

1 reference

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9 February 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21827945%20AND%20SRC:MED&resulttype=core&format=json

The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

9 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

19 March 2017

1 reference

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Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Mechanism of XIAP-mediated inhibition of caspase-9

19 March 2017

1 reference

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Structural basis for the inhibition of caspase-3 by XIAP

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Structure of the Drosophila Apoptosome at 6.9 Å Resolution

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Structural basis for the activation of human procaspase-7

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Dimer formation drives the activation of the cell death protease caspase 9

19 March 2017

1 reference

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EMAN2: an extensible image processing suite for electron microscopy

19 March 2017

1 reference

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EMAN: semiautomated software for high-resolution single-particle reconstructions

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

The apoptosome activates caspase-9 by dimerization

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Structure of the apoptotic protease-activating factor 1 bound to ADP

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Software extensions to UCSF chimera for interactive visualization of large molecular assemblies

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Cell death: critical control points

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

A unified model for apical caspase activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

19 March 2017

Caspases: enemies within

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Molecular mechanisms of caspase regulation during apoptosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Regulation of the Apaf-1-caspase-9 apoptosome

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Structure of an apoptosome-procaspase-9 CARD complex.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Wheel of Life, Wheel of Death: A Mechanistic Insight into Signaling by STAND Proteins.

27 September 2017

1 reference

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A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen

27 September 2017

1 reference

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Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Caspase activation: revisiting the induced proximity model

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

NODs: intracellular proteins involved in inflammation and apoptosis

27 September 2017

1 reference

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Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Caspase-9 and APAF-1 form an active holoenzyme

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Protocol for 3-D visualization of molecules on mica via the quick-freeze, deep-etch technique

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155825

A matter of life and death

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21827945

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21827945

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21827945

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.STR.2011.07.001

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21827945%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21827945%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

2 references