Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3 (Q24315715)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18641304%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18641304%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

GOA release 2020-03-11

cytotoxic T-lymphocyte associated protein 4

1 reference

negative regulation of regulatory T cell differentiation

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Claire Manzotti

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18641304%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Lucy Walker

6

1 reference

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11 January 2020

David M Sansom

7

1 reference

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11 January 2020

author name string

Yong Zheng

1

1 reference

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11 January 2020

Fiona Burke

3

1 reference

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11 January 2020

Laure Dussably

4

1 reference

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11 January 2020

Omar Qureshi

5

1 reference

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11 January 2020

language of work or name

English

0 references

publication date

1 August 2008

1 reference

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11 January 2020

published in

Journal of Immunology

1 reference

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11 January 2020

volume

181

1 reference

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11 January 2020

page(s)

1683-1691

1 reference

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11 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18641304%20AND%20SRC:MED&resulttype=core&format=json

FOXP3 controls regulatory T cell function through cooperation with NFAT

11 January 2020

cites work

1 reference

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Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758479

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

19 March 2017

1 reference

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Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

19 March 2017

1 reference

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Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

19 March 2017

1 reference

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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

19 March 2017

1 reference

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

19 March 2017

1 reference

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

19 March 2017

1 reference

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Control of regulatory T cell development by the transcription factor Foxp3

19 March 2017

1 reference

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Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

19 March 2017

1 reference

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758479

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758479

Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

7 April 2017

1 reference

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Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758479

The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758479

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758479

TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758479

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758479

De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758479

Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restricts clonal expansion of helper T cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758479

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

27 September 2017

1 reference

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Regulatory T cells: key controllers of immunologic self-tolerance

27 September 2017

1 reference

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Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance

27 September 2017

1 reference

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The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.

27 September 2017

1 reference

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Attack on the clones? Human FOXP3 detection by PCH101, 236A/E7, 206D, and 259D reveals 259D as the outlier with lower sensitivity

30 May 2018

1 reference

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Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.

29 November 2018

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Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758479

Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758479

Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function

29 November 2018

1 reference

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CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758479

Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells.

29 November 2018

1 reference

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Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758479

Foxp3-dependent programme of regulatory T-cell differentiation

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18641304

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18641304

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4049/JIMMUNOL.181.3.1683

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18641304%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18641304%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

2 references