cytotoxic T-lymphocyte associated protein 4 (Q2907609)

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mammalian protein found in Homo sapiens

• Cytotoxic T-lymphocyte-associated antigen 4
• CTLA-4
• cytotoxic T-lymphocyte-associated serine esterase-4
• cytotoxic T lymphocyte associated antigen 4 short spliced form
• CD152 isoform
• CTLA4
• ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
• insulin-dependent diabetes mellitus 12
• cytotoxic T-lymphocyte protein 4
• celiac disease 3
• CTLA-4 Antigen

edit

Language	Label	Description	Also known as
English	cytotoxic T-lymphocyte associated protein 4	mammalian protein found in Homo sapiens	Cytotoxic T-lymphocyte-associated antigen 4 CTLA-4 cytotoxic T-lymphocyte-associated serine esterase-4 cytotoxic T lymphocyte associated antigen 4 short spliced form CD152 isoform CTLA4 ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 insulin-dependent diabetes mellitus 12 cytotoxic T-lymphocyte protein 4 celiac disease 3 CTLA-4 Antigen

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P16410

part of

cytotoxic T-lymphocyte antigen 4

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16410

Immunoglobulin-like fold

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16410

Immunoglobulin-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16410

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin V-set domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P16410

encoded by

CTLA4

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P16410

molecular function

protein binding

determination method

IPI

8 references

retrieved

8 April 2019

stated in

CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IPI

retrieved

8 April 2019

stated in

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IPI

retrieved

8 April 2019

stated in

Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IPI

retrieved

8 April 2019

stated in

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IPI

retrieved

8 April 2019

stated in

A secreted protein microarray platform for extracellular protein interaction discovery

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IPI

retrieved

8 April 2019

stated in

PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IPI

retrieved

8 April 2019

stated in

Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IPI

retrieved

8 April 2019

stated in

Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IPI

cell component

perinuclear region of cytoplasm

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IDA

integral component of membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16410

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IEA

clathrin-coated endocytic vesicle

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IDA

plasma membrane

determination method

TAS

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16410

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IEA

Golgi apparatus

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IDA

membrane

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16410

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IEA

external side of plasma membrane

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IDA

protein complex involved in cell adhesion

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IDA

integral component of plasma membrane

determination method

IMP

TAS

2 references

retrieved

8 April 2019

stated in

Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

TAS

retrieved

8 April 2019

stated in

Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab

GOA

curator

UniProt

UniProt protein ID

P16410

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IMP

external side of plasma membrane

determination method

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IBA

biological process

B cell receptor signaling pathway

determination method

IMP

1 reference

retrieved

1 January 2018

stated in

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia

GOA

curator

UniProt

UniProt protein ID

P16410

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IMP

T cell costimulation

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

TAS

negative regulation of B cell proliferation

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia

GOA

curator

UniProt

UniProt protein ID

P16410

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IMP

adaptive immune response

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16410

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IEA

negative regulation of regulatory T cell differentiation

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IDA

immune response

determination method

TAS

IEA

2 references

retrieved

8 April 2019

stated in

Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IEA

cellular response to DNA damage stimulus

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia

GOA

curator

UniProt

UniProt protein ID

P16410

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IMP

immune system process

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P16410

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IEA

positive regulation of apoptotic process

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia

GOA

curator

UniProt

UniProt protein ID

P16410

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IMP

negative regulation of immune response

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IEA

negative regulation of T cell proliferation

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IEA

regulation of regulatory T cell differentiation

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

TAS

regulation of T cell proliferation

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IEA

immune system process

determination method

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16410

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IBA

negative regulation of regulatory T cell differentiation

determination method

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IBA

T cell receptor signaling pathway

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IBA

B cell receptor signaling pathway

determination method

IBA

IMP

2 references

retrieved

8 April 2019

stated in

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia

GOA

curator

UniProt

UniProt protein ID

P16410

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IMP

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16410

determination method

IBA

physically interacts with

ipilimumab

object has role

reaction inhibitor

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

reference URL

https://platform.opentargets.org/drug/CHEMBL1789844

Gene Atlas image

PBB GE CTLA4 221331 x at fs.png
732 × 530; 11 KB

0 references

has part(s)

immunoglobulin subtype

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16410

immunoglobulin V-set domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16410

Identifiers

RefSeq protein ID

NP_001032720

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1493

NP_005205

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1493

UniProt protein ID

P16410

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P16410

Ensembl protein ID

ENSP00000417779

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000417779

ENSP00000295854

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000295854

ENSP00000497102

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000497102

ENSP00000497319

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000497319

Freebase ID

/m/07_mhf

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

21705690

0 references

2910950284

0 references

OpenAlex ID

C21705690

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

3OSK

1 reference

stated in

UniProt

UniProt protein ID

P16410

retrieved

9 August 2016

language of work or name

English

1AH1

1 reference

stated in

UniProt

UniProt protein ID

P16410

retrieved

9 August 2016

language of work or name

English

1H6E

1 reference

stated in

UniProt

UniProt protein ID

P16410

retrieved

9 August 2016

language of work or name

English

1I85

1 reference

stated in

UniProt

UniProt protein ID

P16410

retrieved

9 August 2016

language of work or name

English

1I8L

1 reference

stated in

UniProt

UniProt protein ID

P16410

retrieved

9 August 2016

language of work or name

English

2X44

1 reference

stated in

UniProt

UniProt protein ID

P16410

retrieved

9 August 2016

language of work or name

English

3BX7

1 reference

stated in

UniProt

UniProt protein ID

P16410

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(19 entries)

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• arwiki بروتين مرتبط بالخلايا اللمفاوية التائية السامة 4
• bswiki CTLA4
• cswiki CTLA-4
• cywiki CTLA4
• dewiki CTLA-4
• enwiki Cytotoxic T-lymphocyte associated protein 4
• eswiki CTLA-4
• etwiki CTLA-4
• fawiki CTLA-4
• frwiki CTLA-4
• glwiki CTLA4
• hewiki CTLA-4
• itwiki CTLA-4
• jawiki CTLA-4
• plwiki CTLA-4
• rowiki CTLA-4
• ruwiki CTLA-4
• ukwiki CTLA4
• zhwiki CTLA-4

Wikibooks(0 entries)

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Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q2907609&oldid=2022904033"