p53 Modulates the exonuclease activity of Werner syndrome protein (Q24291371)

2

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J A Sommers

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Q Yang

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X W Wang

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E A Spillare

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C C Harris

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V A Bohr

Journal of Biological Chemistry

8

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language of work or name

English

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publication date

14 September 2001

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published in

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volume

276

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issue

37

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page(s)

35093-102

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The Werner syndrome protein is a DNA helicase

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Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

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Functional and physical interaction between WRN helicase and human replication protein A

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The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

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Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

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Characterization of the human and mouse WRN 3'-->5' exonuclease

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p53-mediated apoptosis is attenuated in Werner syndrome cells

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Physical and functional interaction between p53 and the Werner's syndrome protein

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Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53.

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Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

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The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

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Altered frequency of initiation sites of DNA replication in Werner's syndrome cells

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Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

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inferred from DOI database lookup

7 January 2021

based on heuristic

Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103332200

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1074/JBC.M103332200

1 reference

Consolidated OpenCitations Corpus – April 2017

4711580

4711580

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference