Wnt family member 1 (Q21123961)

http://www.ebi.ac.uk/interpro/protein/P04628

Wnt protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

protein domain specific binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

3 references

1 January 2018

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

The effect on cell growth by Wnt1 RNAi in human neuroblastoma SH-SY5Y cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 reference

1 January 2018

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

signaling receptor binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

receptor ligand activity

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

endocytic vesicle membrane

IC

cell component

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

endoplasmic reticulum lumen

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

extracellular exosome

1 reference

1 January 2018

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

negative regulation of cell-substrate adhesion

biological process

1 reference

1 January 2018

Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

forebrain anterior/posterior pattern specification

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

dopaminergic neuron differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

positive regulation of protein phosphorylation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

myotube differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

metencephalon development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

midbrain-hindbrain boundary maturation during brain development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

T cell differentiation in thymus

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

spinal cord association neuron differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

negative regulation of cell-cell adhesion

1 reference

1 January 2018

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

neuron fate determination

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

signal transduction in response to DNA damage

1 reference

1 January 2018

Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

positive regulation of fibroblast proliferation

1 reference

1 January 2018

Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

positive regulation of dermatome development

1 reference

1 January 2018

SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

negative regulation of cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

hematopoietic stem cell proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

cell proliferation in midbrain

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

hepatocyte differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

negative regulation of transforming growth factor beta receptor signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

cerebellum development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

ubiquitin-dependent SMAD protein catabolic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

negative regulation of BMP signaling pathway

1 reference

1 January 2018

BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

1 reference

24 April 2018

Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04628&geneProductId=UniProtKB:P04628

positive regulation of transcription, DNA-templated

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

diencephalon development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

branching involved in ureteric bud morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

cellular response to peptide hormone stimulus

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

midbrain-hindbrain boundary development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

embryonic brain development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 reference

1 January 2018

Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

positive regulation of insulin-like growth factor receptor signaling pathway

IEP

1 reference

1 January 2018

Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

inner ear morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

animal organ regeneration

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

positive regulation of cell population proliferation

3 references

1 January 2018

Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

negative regulation of ubiquitin-dependent protein catabolic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

neuron fate commitment

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

positive regulation of lamellipodium assembly

1 reference

1 January 2018

The effect on cell growth by Wnt1 RNAi in human neuroblastoma SH-SY5Y cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 reference

1 January 2018

Mutations in WNT1 cause different forms of bone fragility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

positive regulation of Notch signaling pathway

1 reference

1 January 2018

Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

positive regulation of transcription by RNA polymerase II

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04628&geneProductId=UniProtKB:P04628

Wnt signaling pathway

5 references

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04628&geneProductId=UniProtKB:P04628

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04628&geneProductId=UniProtKB:P04628

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04628&geneProductId=UniProtKB:P04628

24 April 2018

Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04628&geneProductId=UniProtKB:P04628

astrocyte-dopaminergic neuron signaling

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

positive regulation of canonical Wnt signaling pathway

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04628&geneProductId=UniProtKB:P04628

Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

2 references

1 January 2018

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

midbrain dopaminergic neuron differentiation

NAS

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

Wnt signaling pathway, planar cell polarity pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

beta-catenin destruction complex disassembly

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

negative regulation of oxidative stress-induced neuron death

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

regulation of signaling receptor activity

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

canonical Wnt signaling pathway

9 references

1 January 2018

A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

The effect on cell growth by Wnt1 RNAi in human neuroblastoma SH-SY5Y cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04628&geneProductId=UniProtKB:P04628

Wnt signaling pathway

4 references

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04628&geneProductId=UniProtKB:P04628

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04628&geneProductId=UniProtKB:P04628

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04628&geneProductId=UniProtKB:P04628

negative regulation of apoptotic process

1 reference

1 January 2018

Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

Wnt signaling pathway

5 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

neuron differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04628

Wnt protein, conserved site

has part(s)

1 reference

stated in

InterPro Release 71.0