Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. (Q41412892)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28733458%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

title

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28733458%20AND%20SRC:MED&resulttype=core&format=json

canonical Wnt signaling pathway

25 March 2020

main subject

CRISPR

0 references

1 reference

GOA release 2020-03-11

author

Michael Boutros

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28733458%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

author name string

Oksana Voloshanenko

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28733458%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

Philipp Gmach

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28733458%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

Jan Winter

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28733458%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

Dominique Kranz

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28733458%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

language of work or name

English

0 references

publication date

21 July 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28733458%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

number of pages

13

1 reference

based on heuristic

inferred from page(s)

published in

FASEB Journal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28733458%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

volume

31

1 reference

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25 March 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28733458%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

page(s)

4832-4844

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28733458%20AND%20SRC:MED&resulttype=core&format=json

Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

25 March 2020

cites work

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2 December 2018

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12 December 2020

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Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs.

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11 June 2018

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11 June 2018

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11 June 2018

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Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance

11 June 2018

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Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining.

11 June 2018

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Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations

11 June 2018

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Can we safely target the WNT pathway?

11 June 2018

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Development and applications of CRISPR-Cas9 for genome engineering

11 June 2018

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Targeted genomic rearrangements using CRISPR/Cas technology

11 June 2018

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Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells

11 June 2018

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WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3

11 June 2018

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Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish.

11 June 2018

1 reference

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Responses of hair follicle-associated structures to loss of planar cell polarity signaling

11 June 2018

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Multiplex genome engineering using CRISPR/Cas systems

11 June 2018

1 reference

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WNT signalling pathways as therapeutic targets in cancer

11 June 2018

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11 June 2018

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Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.

11 June 2018

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The complex world of WNT receptor signalling

11 June 2018

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Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes

11 June 2018

1 reference

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Active Wnt proteins are secreted on exosomes.

11 June 2018

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Dvl3 translocates IPMK to the cell membrane in response to Wnt.

11 June 2018

1 reference

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A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities

11 June 2018

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A genome-wide RNA interference screen identifies caspase 4 as a factor required for tumor necrosis factor alpha signaling.

11 June 2018

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Primer3--new capabilities and interfaces

11 June 2018

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Wnt/β-catenin signaling and disease

11 June 2018

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Structural basis of Wnt recognition by Frizzled

11 June 2018

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Porcupine-mediated lipidation is required for Wnt recognition by Wls.

11 June 2018

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Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

11 June 2018

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Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes.

11 June 2018

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International Union of Basic and Clinical Pharmacology. LXXX. The class Frizzled receptors

11 June 2018

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Development of a bioassay for detection of Wnt-binding affinities for individual frizzled receptors

11 June 2018

1 reference

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Proximal events in Wnt signal transduction

11 June 2018

1 reference

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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

11 June 2018

1 reference

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Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5636703

Wnt7a interaction with Fzd5 and detection of signaling activation using a split eGFP

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5636703

Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5636703

Secretion of Wnt ligands requires Evi, a conserved transmembrane protein

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5636703

Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5636703

The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells

11 June 2018

1 reference

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Analysis of the cytogenetic stability of the human embryonal kidney cell line 293 by cytogenetic and STR profiling approaches

11 June 2018

1 reference

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Frizzled6 controls hair patterning in mice

11 June 2018

1 reference

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The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

11 June 2018

1 reference

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Wnt proteins are lipid-modified and can act as stem cell growth factors

11 June 2018

1 reference

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Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains

11 June 2018

1 reference

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Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

11 June 2018

1 reference

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The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5636703

A new member of the frizzled family from Drosophila functions as a Wingless receptor

11 June 2018

1 reference

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11 June 2018

Wnt signaling in cancer.

1 reference

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Fatty acylation of Wnt proteins

19 August 2018

1 reference

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Genome engineering using CRISPR-Cas9 system.

19 August 2018

1 reference

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E-CRISP: fast CRISPR target site identification.

19 August 2018

1 reference

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Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine.

19 August 2018

1 reference

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RAB8B is required for activity and caveolar endocytosis of LRP6.

19 August 2018

1 reference

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Wnt3a stimulation elicits G-protein-coupled receptor properties of mammalian Frizzled proteins.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5636703

frizzled and frizzled 2 play a partially redundant role in wingless signaling and have similar requirements to wingless in neurogenesis.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5636703

19 August 2018

Identifiers

DOI

10.1096/FJ.201700144R

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28733458%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28733458%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

1 reference