Cell division cycle 42 (Q1198053)

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mammalian protein found in Homo sapiens
  • cell division control protein 42 homolog
  • G25K GTP-binding protein
  • CDC42
  • dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))
  • GTP binding protein, 25kDa
  • small GTP binding protein CDC42
  • dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
  • growth-regulating protein
edit
Language Label Description Also known as
English
Cell division cycle 42
mammalian protein found in Homo sapiens
  • cell division control protein 42 homolog
  • G25K GTP-binding protein
  • CDC42
  • dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))
  • GTP binding protein, 25kDa
  • small GTP binding protein CDC42
  • dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
  • growth-regulating protein

Statements

molecular function
protein binding
determination method
IPI
52 references
retrieved
8 April 2019
stated in
Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium
GOA
curator
dictyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis
GOA
curator
dictyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas
GOA
curator
UniProt
UniProt protein ID
P60953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
SPECs, small binding proteins for Cdc42
GOA
curator
UniProt
UniProt protein ID
P60953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis
GOA
curator
UniProt
UniProt protein ID
P60953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I
GOA
curator
UniProt
UniProt protein ID
P60953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis
GOA
curator
UniProt
UniProt protein ID
P60953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes
GOA
curator
UniProt
UniProt protein ID
P60953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading
GOA
curator
UniProt
UniProt protein ID
P60953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure
GOA
curator
UniProt
UniProt protein ID
P60953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Activation of endogenous Cdc42 visualized in living cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Bni1p, a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative mass spectrometry catalogues Salmonella pathogenicity island-2 effectors and identifies their cognate host binding partners
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of the Salmonella Typhimurium effector protein SopB with host cell Cdc42 is involved in intracellular replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Invasion of breast cancer cells into collagen matrix requires TGF-α and Cdc42 signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Group I and II mammalian PAKs have different modes of activation by Cdc42
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Identification and characterization of the Cdc42-binding site of IQGAP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Blebbishields, the emergency program for cancer stem cells: sphere formation and tumorigenesis after apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
The small GTPase RalA targets filamin to induce filopodia
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of the Salmonella Typhimurium effector protein SopB with host cell Cdc42 is involved in intracellular replication
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
GTP binding
determination method
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P60953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IEA
retrieved
8 April 2019
stated in
TIM, a Dbl-related protein, regulates cell shape and cytoskeletal organization in a Rho-dependent manner
GOA
curator
UniProt
UniProt protein ID
P60953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IDA
retrieved
8 April 2019
stated in
CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IDA
retrieved
8 April 2019
stated in
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IBA
protein kinase binding
determination method
IBA
IDA
IPI
5 references
retrieved
8 April 2019
stated in
Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome
GOA
curator
UniProt
UniProt protein ID
P60953
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IPI
retrieved
8 April 2019
stated in
AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60953
determination method
IBA
cell component
biological process
Gene Atlas image
PBB GE CDC42 208728 s at fs.png
732 × 530; 11 KB
0 references
Commons category
CDC42
0 references

Identifiers

PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q1198053&oldid=2022903129"