Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer (Q24301750)

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N Modi

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A M Stewart

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R I Hieronimus

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J Liu

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D H Gutmann

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D N Chadee

Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase

7

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language of work or name

English

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publication date

17 February 2011

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published in

Oncogene

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volume

30

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issue

7

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page(s)

781-9

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cites work

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Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1

19 March 2017

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Protein 4.1 tumor suppressors: getting a FERM grip on growth regulation

19 March 2017

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Schwannomin isoform-1 interacts with syntenin via PDZ domains

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19 March 2017

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The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility

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Merlin, the neurofibromatosis type 2 gene product, and beta1 integrin associate in isolated and differentiating Schwann cells

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Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours

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Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac.

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Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK.

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Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3.

27 September 2017

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Merlin facilitates ubiquitination and degradation of transactivation-responsive RNA-binding protein.

27 September 2017

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Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane

27 September 2017

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The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression

27 September 2017

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Merlin and the ERM proteins in Schwann cells, neurons and growth cones

27 September 2017

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A genetically defined model for human ovarian cancer

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Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation

27 September 2017

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Constitutive JNK activation in NIH 3T3 fibroblasts induces a partially transformed phenotype

27 September 2017

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Establishment and characterization of a schwannoma cell line from a patient with neurofibromatosis 2.

27 September 2017

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Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain

27 September 2017

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Zipper-mediated oligomerization of the mixed lineage kinase SPRK/MLK-3 is not required for its activation by the GTPase cdc 42 but Is necessary for its activation of the JNK pathway. Monomeric SPRK L410P does not catalyze the activating phosphorylat

27 September 2017

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The JNK/SAPK activator mixed lineage kinase 3 (MLK3) transforms NIH 3T3 cells in a MEK-dependent fashion

27 September 2017

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The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.

27 September 2017

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Tumor induction by activated JNK occurs through deregulation of cellular growth

27 September 2017

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The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

30 May 2018

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The neurofibromatosis type 2 gene product, schwannomin, suppresses growth of NIH 3T3 cells

30 May 2018

1 reference

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A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation

30 May 2018

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Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology

21 January 2018

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Inhibition of NF2-negative and NF2-positive primary human meningioma cell proliferation by overexpression of merlin due to vector-mediated gene transfer

21 January 2018

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c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells.

21 January 2018

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Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.453

Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.453

Interdomain binding mediates tumor growth suppression by the NF2 gene product

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.453

Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.453

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.453

1 reference

Dimensions Publication ID

1493810

1005129609

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Fatcat ID

release_dm7utaf5mbdpfihwp5cg6ykqbq

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1493810

1 reference

1 reference

1 reference