WASP actin nucleation promoting factor (Q8027658)

Wiskott-Aldrich syndrome protein

1 reference

Wiscott-Aldrich syndrome protein, C-terminal

1 reference

PH-like domain superfamily

1 reference

WH1/EVH1 domain, protein family

1 reference

CRIB domain, protein family

1 reference

WASP family, EVH1 domain, protein family

1 reference

WH2 domain, protein family

1 reference

Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways

1 reference

13 November 2019

1 reference

13 November 2019

phospholipase binding

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

GTPase regulator activity

IPI

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

20 references

8 April 2019

The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

WASP suppresses the growth defect of Saccharomyces cerevisiae las17Delta strain in the presence of WIP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

A human MAP kinase interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Phosphorylation of WASp is a key regulator of activity and stability in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Activation of endogenous Cdc42 visualized in living cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

identical protein binding

IPI

4 references

8 April 2019

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways

protein kinase binding

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

IPI

actin filament binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

extracellular exosome

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42768&geneProductId=UniProtKB:P42768

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

1 reference

17 October 2017

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42768&geneProductId=UniProtKB:P42768

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

8 April 2019

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

site of double-strand break

1 reference

8 April 2019

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

1 reference

8 April 2019

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

Fc-gamma receptor signaling pathway involved in phagocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

actin filament organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

negative regulation of cell motility

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

1 reference

8 April 2019

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

positive regulation of Arp2/3 complex-mediated actin nucleation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

actin filament-based movement

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42768&geneProductId=UniProtKB:P42768

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

actin filament polymerization

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42768&geneProductId=UniProtKB:P42768

regulation of T cell antigen processing and presentation

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

1 reference

8 April 2019

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

epidermis development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

T cell receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

regulation of catalytic activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

Rho protein signal transduction

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

regulation of actin polymerization or depolymerization

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

regulation of lamellipodium assembly

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

Cdc42 protein signal transduction

IGI

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

regulation of stress fiber assembly

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

negative regulation of stress fiber assembly

IGI

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

actin cortical patch assembly

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

positive regulation of actin nucleation

IDA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

actin cortical patch localization

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

protein-containing complex assembly

1 reference

8 April 2019

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

cellular response to interferon-gamma

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

positive regulation of double-strand break repair via homologous recombination

1 reference

8 April 2019

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

regulation of double-strand break repair via nonhomologous end joining

IDA

1 reference

8 April 2019

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42768

https://docs.openalex.org/download-snapshot/snapshot-data-format

IDA

Gene Atlas image

PBB GE WAS 38964 r at fs.png
732 × 530; 11 KB

0 references

Commons category

Wiskott-Aldrich syndrome

0 references

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016