Signal transducer and activator of transcription 6 (Q7394700)

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mammalian protein found in Homo sapiens

STAT, interleukin4-induced
signal transducer and activator of transcription 6, interleukin-4 induced
signal transducer and activator of transcription 6
IL-4 Stat
transcription factor IL-4 STAT
STAT6

Language	Label	Description	Also known as
English	Signal transducer and activator of transcription 6	mammalian protein found in Homo sapiens	STAT, interleukin4-induced signal transducer and activator of transcription 6, interleukin-4 induced signal transducer and activator of transcription 6 IL-4 Stat transcription factor IL-4 STAT STAT6

Statements

1 reference

13 November 2019

UniProt protein ID

p53-like transcription factor, DNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42226

STAT transcription factor, DNA-binding, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42226

transcription factor STAT

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42226

STAT transcription factor, coiled coil

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42226

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42226

STAT transcription factor, N-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42226

STAT transcription factor, protein interaction, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

STAT6, SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

STAT6, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

STAT transcription factor, DNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

STAT transcription factor, all-alpha domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

identical protein binding

determination method

1 reference

9 May 2019

Activation of STAT6 by STING is critical for antiviral innate immunity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

sequence-specific DNA binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

protein phosphatase binding

determination method

1 reference

9 May 2019

T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

protein binding

determination method

5 references

9 May 2019

Signal transducer and activator of transcription 6 directly regulates human ORMDL3 expression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

9 May 2019

Mutational analysis of the STAT6 SH2 domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

9 May 2019

Activation of STAT6 by STING is critical for antiviral innate immunity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

9 May 2019

Requirements for interleukin-4-induced gene expression and functional characterization of Stat6

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

9 May 2019

The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

DNA-binding transcription factor activity

determination method

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

9 May 2019

Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

1 reference

8 April 2019

Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

9 May 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

9 May 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

9 May 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

nuclear membrane

determination method

1 reference

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

determination method

biological process

regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

T-helper 1 cell lineage commitment

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

regulation of cell population proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

response to cytokine

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

cellular response to hydrogen peroxide

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

mammary gland epithelial cell proliferation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

cellular response to reactive nitrogen species

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

positive regulation of type I interferon production

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

positive regulation of isotype switching to IgE isotypes

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

mammary gland morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

negative regulation of type 2 immune response

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

signal transduction

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42226&geneProductId=UniProtKB:P42226

determination method

transcription by RNA polymerase II

determination method

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42226&geneProductId=UniProtKB:P42226

determination method

defense response

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

receptor signaling pathway via JAK-STAT

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

cytokine-mediated signaling pathway

determination method

response to peptide hormone

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

9 May 2019

Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

growth hormone receptor signaling pathway via JAK-STAT

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42226

determination method

Gene Atlas image

PBB GE STAT6 201331 s at fs.png
732 × 530; 11 KB

0 references

STAT6, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42226

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42226

STAT transcription factor, all-alpha domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42226

STAT transcription factor, DNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42226

STAT transcription factor, protein interaction

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42226

STAT6, SH2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42226

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000451742

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451742

ENSP00000300134

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000300134

ENSP00000401486

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000401486

ENSP00000438451

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000438451

ENSP00000444530

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000444530

ENSP00000445409

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000445409

ENSP00000450428

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450428

ENSP00000450510

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450510

ENSP00000450665

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450665

ENSP00000450732

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450732

ENSP00000450747

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450747

ENSP00000451074

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451074

ENSP00000451546

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451546

ENSP00000451909

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451909

ENSP00000452203

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000452203

ENSP00000452373

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000452373

ENSP00000452394

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000452394

ENSP00000491116

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000491116

ENSP00000498693

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000498693

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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