Nuclear receptor corepressor 1 (Q7068191)

From Wikidata
Jump to navigation Jump to search
mammalian protein found in Homo sapiens
  • nuclear receptor corepressor 1
  • NCOR1
  • TRAC1
  • N-CoR
  • hN-CoR
  • protein phosphatase 1, regulatory subunit 109
  • PPP1R109
  • thyroid hormone- and retinoic acid receptor-associated corepressor 1
  • N-CoR1
edit
Language Label Description Also known as
English
Nuclear receptor corepressor 1
mammalian protein found in Homo sapiens
  • nuclear receptor corepressor 1
  • NCOR1
  • TRAC1
  • N-CoR
  • hN-CoR
  • protein phosphatase 1, regulatory subunit 109
  • PPP1R109
  • thyroid hormone- and retinoic acid receptor-associated corepressor 1
  • N-CoR1

Statements

image
Protein NCOR1 PDB 2EQR.png
1,200 × 1,000; 93 KB
0 references
molecular function
protein binding
determination method
IPI
23 references
retrieved
9 May 2019
stated in
Novel regulatory role for human Acf1 in transcriptional repression of vitamin D3 receptor-regulated genes
GOA
curator
UniProt
UniProt protein ID
O75376
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2
GOA
curator
UniProt
UniProt protein ID
O75376
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
FBI-1 functions as a novel AR co-repressor in prostate cancer cells
GOA
curator
UniProt
UniProt protein ID
O75376
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1
GOA
curator
UniProt
UniProt protein ID
O75376
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
The functional interactome landscape of the human histone deacetylase family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
DACH1 inhibits transforming growth factor-beta signaling through binding Smad4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
Enhancer activation requires trans-recruitment of a mega transcription factor complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
Structural Basis for Iloprost as a Dual Peroxisome Proliferator-activated Receptor  /  Agonist
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
Structure of Rev-erbα bound to N-CoR reveals a unique mechanism of nuclear receptor–co-repressor interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
retrieved
9 May 2019
stated in
HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IPI
transcription corepressor activity
determination method
IBA
IDA
IMP
TAS
6 references
retrieved
9 May 2019
stated in
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
TAS
retrieved
9 May 2019
stated in
FBI-1 functions as a novel AR co-repressor in prostate cancer cells
GOA
curator
UniProt
UniProt protein ID
O75376
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IMP
retrieved
9 May 2019
stated in
Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1
GOA
curator
UniProt
UniProt protein ID
O75376
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IMP
retrieved
9 May 2019
stated in
The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IMP
retrieved
9 May 2019
stated in
The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IBA
cell component
biological process
negative regulation of transcription by RNA polymerase II
determination method
TAS
IMP
5 references
retrieved
17 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376
determination method
TAS
retrieved
17 October 2017
stated in
Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1
GOA
curator
UniProt
UniProt protein ID
O75376
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376
determination method
IMP
retrieved
17 October 2017
stated in
The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376
determination method
IMP
retrieved
17 October 2017
stated in
SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376
determination method
IMP
retrieved
17 October 2017
stated in
MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75376&geneProductId=UniProtKB:O75376
determination method
IMP
negative regulation of transcription by RNA polymerase II
determination method
IBA
IMP
TAS
6 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
TAS
retrieved
9 May 2019
stated in
Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1
GOA
curator
UniProt
UniProt protein ID
O75376
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IMP
retrieved
9 May 2019
stated in
SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IMP
retrieved
9 May 2019
stated in
MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IMP
retrieved
9 May 2019
stated in
The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IMP
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75376
determination method
IBA

Identifiers

MeSH descriptor ID
D056971
subject named as
Nuclear Receptor Co-Repressor 1
0 references
RefSeq protein ID
 
edit
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q7068191&oldid=2022909470"