SMAD family member 1 (Q699999)

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mammalian protein found in Homo sapiens
  • TGF-beta signaling protein 1
  • mothers against decapentaplegic homolog 1
  • SMAD, mothers against DPP homolog 1
  • transforming growth factor-beta signaling protein 1
  • SMAD 1
  • JV4-1
  • hSMAD1
  • BSP-1
  • mothers against DPP homolog 1
  • MAD, mothers against decapentaplegic homolog 1
  • Mad-related protein 1
  • SMAD1
  • Transforming growth factor-beta-signaling protein 1
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Language Label Description Also known as
English
SMAD family member 1
mammalian protein found in Homo sapiens
  • TGF-beta signaling protein 1
  • mothers against decapentaplegic homolog 1
  • SMAD, mothers against DPP homolog 1
  • transforming growth factor-beta signaling protein 1
  • SMAD 1
  • JV4-1
  • hSMAD1
  • BSP-1
  • mothers against DPP homolog 1
  • MAD, mothers against decapentaplegic homolog 1
  • Mad-related protein 1
  • SMAD1
  • Transforming growth factor-beta-signaling protein 1

Statements

subclass of
R-SMAD
0 references
molecular function
protein binding
determination method
IPI
22 references
retrieved
8 April 2019
stated in
Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome
GOA
curator
UniProt
UniProt protein ID
Q15797
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling
GOA
curator
UniProt
UniProt protein ID
Q15797
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation
GOA
curator
UniProt
UniProt protein ID
Q15797
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines
GOA
curator
UniProt
UniProt protein ID
Q15797
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling
GOA
curator
UniProt
UniProt protein ID
Q15797
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
USP15 is a deubiquitylating enzyme for receptor-activated SMADs
GOA
curator
UniProt
UniProt protein ID
Q15797
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Ubiquitin C-terminal hydrolase-L3 regulates Smad1 ubiquitination and osteoblast differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis of Smad1 activation by receptor kinase phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Functional proteomics mapping of a human signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Charting the molecular links between driver and susceptibility genes in colorectal cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
SMAD proteins control DROSHA-mediated microRNA maturation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
SMAD proteins control DROSHA-mediated microRNA maturation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
retrieved
8 April 2019
stated in
Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IPI
cell component
nucleus
determination method
NAS
IDA
ISS
TAS
IEA
7 references
retrieved
8 April 2019
stated in
Holding their own: the noncanonical roles of Smad proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
TAS
retrieved
8 April 2019
stated in
TGF-beta signal transduction
GOA
curator
UniProt
UniProt protein ID
Q15797
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q15797
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IEA
retrieved
8 April 2019
stated in
MADR1, a MAD-related protein that functions in BMP2 signaling pathways
GOA
curator
UniProt
UniProt protein ID
Q15797
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IDA
retrieved
8 April 2019
stated in
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IDA
biological process
BMP signaling pathway
determination method
IDA
ISS
TAS
IMP
IEA
9 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
TAS
retrieved
8 April 2019
stated in
Holding their own: the noncanonical roles of Smad proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q15797
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
ISS
retrieved
8 April 2019
stated in
Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IEA
retrieved
8 April 2019
stated in
MADR1, a MAD-related protein that functions in BMP2 signaling pathways
GOA
curator
UniProt
UniProt protein ID
Q15797
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IDA
retrieved
8 April 2019
stated in
SMAD proteins control DROSHA-mediated microRNA maturation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IDA
retrieved
8 April 2019
stated in
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797
determination method
IDA
Gene Atlas image
PBB GE SMAD1 210993 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D051898
subject named as
Smad1 Protein
0 references
 
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