Mitogen-activated protein kinase 14 (Q6714402)

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mammalian protein found in Homo sapiens
  • mitogen-activated protein kinase 14
  • mitogen-activated protein kinase p38 alpha
  • p38 mitogen activated protein kinase
  • Cytokine suppressive anti-inflammatory drug-binding protein
  • stress-activated protein kinase 2A
  • CSBP
  • MAP kinase 14
  • p38alpha Exip
  • MAP kinase Mxi2
  • MAX-interacting protein 2
  • MAP kinase p38 alpha
  • p38 MAP kinase
  • CSAID-binding protein
  • cytokine suppressive anti-inflammatory drug binding protein
  • MAPK14
  • Csaids binding protein
  • SAPK2a
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Language Label Description Also known as
English
Mitogen-activated protein kinase 14
mammalian protein found in Homo sapiens
  • mitogen-activated protein kinase 14
  • mitogen-activated protein kinase p38 alpha
  • p38 mitogen activated protein kinase
  • Cytokine suppressive anti-inflammatory drug-binding protein
  • stress-activated protein kinase 2A
  • CSBP
  • MAP kinase 14
  • p38alpha Exip
  • MAP kinase Mxi2
  • MAX-interacting protein 2
  • MAP kinase p38 alpha
  • p38 MAP kinase
  • CSAID-binding protein
  • cytokine suppressive anti-inflammatory drug binding protein
  • MAPK14
  • Csaids binding protein
  • SAPK2a

Statements

molecular function
MAP kinase activity
determination method
IDA
IEA
6 references
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q16539
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16539&geneProductId=UniProtKB:Q16539
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16539&geneProductId=UniProtKB:Q16539
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16539&geneProductId=UniProtKB:Q16539
determination method
IEA
retrieved
16 July 2018
stated in
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization
GOA
curator
UniProt
UniProt protein ID
Q16539
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16539&geneProductId=UniProtKB:Q16539
determination method
IDA
retrieved
16 July 2018
stated in
Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors
GOA
curator
UniProt
UniProt protein ID
Q16539
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16539&geneProductId=UniProtKB:Q16539
determination method
IDA
retrieved
16 July 2018
stated in
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
GOA
curator
UniProt
UniProt protein ID
Q16539
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16539&geneProductId=UniProtKB:Q16539
determination method
IDA
protein binding
determination method
IPI
26 references
retrieved
8 April 2019
stated in
LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1)
GOA
curator
UniProt
UniProt protein ID
Q16539
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
Metal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
Mxi2 promotes stimulus-independent ERK nuclear translocation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IPI
MAP kinase activity
determination method
IBA
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q16539
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IEA
retrieved
8 April 2019
stated in
Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors
GOA
curator
UniProt
UniProt protein ID
Q16539
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IDA
retrieved
8 April 2019
stated in
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
GOA
curator
UniProt
UniProt protein ID
Q16539
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IDA
retrieved
8 April 2019
stated in
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization
GOA
curator
UniProt
UniProt protein ID
Q16539
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16539
determination method
IBA
cell component
biological process
physically interacts with
Gene Atlas image
PBB GE MAPK14 202530 at fs.png
732 × 530; 11 KB
0 references

Identifiers

PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q6714402&oldid=2022908980"