SAMHD1 acts at stalled replication forks to prevent interferon induction (Q57753937)

SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

ribonuclease activity

1 reference

GOA release 2020-03-11

Flavie Coquel

1

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Sushma Sharma

Sushma Sharma

5

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Hervé Técher

Hervé Técher

3

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Wojciech Niedzwiedz

Wojciech Niedzwiedz

14

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Clément Mettling

Clément Mettling

7

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Andrei Chabes

Andrei Chabes

18

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Philippe Pasero

Philippe Pasero

21

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Vincenzo Costanzo

Vincenzo Costanzo

16

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author name string

Flavie Coquel

1

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Maria-Joao Silva

2

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Hervé Técher

3

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Karina Zadorozhny

4

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Sushma Sharma

5

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Jadwiga Nieminuszczy

6

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Clément Mettling

7

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Elodie Dardillac

8

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Antoine Barthe

9

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Anne-Lyne Schmitz

10

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Alexy Promonet

11

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Alexandra Cribier

12

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Amélie Sarrazin

13

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Wojciech Niedzwiedz

14

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Bernard Lopez

15

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Vincenzo Costanzo

16

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Lumir Krejci

17

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Andrei Chabes

18

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Monsef Benkirane

19

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Yea-Lih Lin

20

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Philippe Pasero

https://scigraph.springernature.com/pub.10.1038/s41586-018-0050-1

21

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language of work or name

English

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publication date

May 2018

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18 April 2018

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published in

Nature

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volume

557

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issue

7703

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page(s)

57-61

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exact match

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cites work

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

1 reference

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7 January 2021

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

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Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

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7 January 2021

The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation

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7 January 2021

Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.

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7 January 2021

Aicardi-Goutières syndrome and the type I interferonopathies

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7 January 2021

Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease

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7 January 2021

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

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7 January 2021

Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.

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7 January 2021

Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1.

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7 January 2021

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome

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7 January 2021

SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity

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7 January 2021

Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction.

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7 January 2021

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

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7 January 2021

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

1 reference

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7 January 2021

Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance

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7 January 2021

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.

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7 January 2021

Causes and consequences of replication stress

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7 January 2021

Nucleases Acting at Stalled Forks: How to Reboot the Replication Program with a Few Shortcuts

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7 January 2021

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

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7 January 2021

Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

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7 January 2021

Replication fork stability confers chemoresistance in BRCA-deficient cells

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7 January 2021

Knockout of cGAS and STING Rescues Virus Infection of Plasmid DNA-Transfected Cells

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7 January 2021

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.

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7 January 2021

Analysis of protein dynamics at active, stalled, and collapsed replication forks.

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7 January 2021

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

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7 January 2021

SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication

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7 January 2021

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

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7 January 2021

BRCA1 accelerates CtIP-mediated DNA-end resection

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7 January 2021

Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context

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7 January 2021

SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.

1 reference

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7 January 2021

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0050-1

7 January 2021

Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

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7 January 2021

DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity

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https://api.crossref.org/works/10.1038%2FS41586-018-0050-1

7 January 2021

Genome-derived cytosolic DNA mediates type I interferon-dependent rejection of B cell lymphoma cells

1 reference

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7 January 2021

The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells.

1 reference

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7 January 2021

RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA

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https://api.crossref.org/works/10.1038%2FS41586-018-0050-1

7 January 2021

cGAS surveillance of micronuclei links genome instability to innate immunity

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7 January 2021

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy

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7 January 2021

High efficiency cell-specific targeting of cytokine activity

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7 January 2021

Feline immunodeficiency virus vectors for efficient transduction of primary human synoviocytes: application to an original model of rheumatoid arthritis

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7 January 2021

Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

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7 January 2021

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

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7 January 2021

Determination of deoxyribonucleoside triphosphate concentrations in yeast cells by strong anion-exchange high-performance liquid chromatography coupled with ultraviolet detection.

1 reference

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7 January 2021

Xenopus laevis as Model System to Study DNA Damage Response and Replication Fork Stability.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0050-1

7 January 2021

Studying DNA Replication Fork Stability in Xenopus Egg Extract

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0050-1

7 January 2021

GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0050-1

7 January 2021

Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0050-1

7 January 2021

Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0050-1

7 January 2021

Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermediates.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-018-0050-1

7 January 2021

Unwinding of synthetic replication and recombination substrates by Srs2.

1 reference

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7 January 2021