glycogen synthase kinase 3 beta (Q5514576)

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mammalian protein found in Homo sapiens
  • glycogen synthase kinase-3 beta
  • GSK-3 beta
  • GSK3beta isoform
  • serine/threonine-protein kinase GSK3B
  • GSK3B
  • 2.7.11.1
edit
Language Label Description Also known as
English
glycogen synthase kinase 3 beta
mammalian protein found in Homo sapiens
  • glycogen synthase kinase-3 beta
  • GSK-3 beta
  • GSK3beta isoform
  • serine/threonine-protein kinase GSK3B
  • GSK3B
  • 2.7.11.1

Statements

molecular function
protein serine/threonine kinase activity
determination method
IDA
ISS
IEA
TAS
11 references
retrieved
26 September 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
determination method
TAS
retrieved
26 September 2017
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
determination method
ISS
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
determination method
IEA
retrieved
26 September 2017
stated in
Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
26 September 2017
stated in
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
26 September 2017
stated in
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
26 September 2017
stated in
GSK3B polymorphisms alter transcription and splicing in Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
26 September 2017
stated in
Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
26 September 2017
stated in
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
26 September 2017
stated in
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
26 September 2017
stated in
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49841&geneProductId=UniProtKB:P49841
determination method
IDA
protein binding
determination method
IPI
70 references
retrieved
9 May 2019
stated in
Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Human dynamin-like protein interacts with the glycogen synthase kinase 3beta
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Oncogenic function of DACT1 in colon cancer through the regulation of β-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Vimentin is a novel AKT1 target mediating motility and invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
NOK/STYK1 interacts with GSK-3β and mediates Ser9 phosphorylation through activated Akt
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Phosphorylation of NBR1 by GSK3 modulates protein aggregation.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
retrieved
9 May 2019
stated in
Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IPI
protein serine/threonine kinase activity
determination method
IDA
IEA
IMP
ISS
NAS
TAS
15 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
TAS
retrieved
9 May 2019
stated in
Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
NAS
retrieved
9 May 2019
stated in
Roles of tau protein in health and disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
NAS
retrieved
9 May 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
ISS
retrieved
9 May 2019
stated in
GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IEA
retrieved
9 May 2019
stated in
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
GSK3B polymorphisms alter transcription and splicing in Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
cell component
cytoplasm
determination method
IDA
IEA
6 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IEA
retrieved
9 May 2019
stated in
ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
beta-catenin destruction complex
determination method
IDA
TAS
6 references
retrieved
9 May 2019
stated in
Glycogen synthase kinase 3: more than a namesake
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
TAS
retrieved
9 May 2019
stated in
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
TAS
retrieved
9 May 2019
stated in
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
biological process
peptidyl-serine phosphorylation
determination method
IDA
5 references
retrieved
9 May 2019
stated in
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
protein phosphorylation
determination method
IDA
IEA
IMP
TAS
6 references
retrieved
9 May 2019
stated in
A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
TAS
retrieved
9 May 2019
stated in
GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IEA
retrieved
9 May 2019
stated in
ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells
GOA
curator
UniProt
UniProt protein ID
P49841
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
GSK3B polymorphisms alter transcription and splicing in Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
retrieved
9 May 2019
stated in
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49841
determination method
IDA
Gene Atlas image
PBB GE GSK3B 209945 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D000071679
subject named as
Glycogen Synthase Kinase 3 beta
0 references
PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q5514576&oldid=2245735264"