GLI family zinc finger 1 (Q5513619)

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mammalian protein found in Homo sapiens

oncogene GLI
GLI1
zinc finger protein GLI1
Glioma-associated oncogene
glioma-associated oncogene homolog 1 (zinc finger protein)
glioma-associated oncogene 1
GLI-Kruppel family member GLI1

Language	Label	Description	Also known as
English	GLI family zinc finger 1	mammalian protein found in Homo sapiens	oncogene GLI GLI1 zinc finger protein GLI1 Glioma-associated oncogene glioma-associated oncogene homolog 1 (zinc finger protein) glioma-associated oncogene 1 GLI-Kruppel family member GLI1

Statements

1 reference

13 November 2019

UniProt protein ID

Zinc finger protein GLI1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08151

Zinc finger C2H2 superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08151

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

sequence-specific DNA binding

determination method

1 reference

24 April 2018

A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08151&geneProductId=UniProtKB:P08151

determination method

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

9 May 2019

CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

microtubule binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

protein binding

determination method

14 references

9 May 2019

Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Physical and functional interactions between Zic and Gli proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Tumor suppressor protein VHL inhibits Hedgehog-Gli activation through suppression of Gli1 nuclear localization

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Gli regulation by the opposing activities of fused and suppressor of fused

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

The crosstalk of mTOR/S6K1 and Hedgehog pathways

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Physical and functional interactions between Zic and Gli proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

nucleic acid binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

determination method

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08151&geneProductId=UniProtKB:P08151

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

9 May 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

chromatin binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

determination method

7 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Physical and functional interactions between Zic and Gli proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Inhibition of GLI1 gene activation by Patched1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

determination method

3 references

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Physical and functional interactions between Zic and Gli proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Gli regulation by the opposing activities of fused and suppressor of fused

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

biological process

epidermal cell differentiation

determination method

1 reference

9 May 2019

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

proximal/distal pattern formation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

cell differentiation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

regulation of transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08151&geneProductId=UniProtKB:P08151

determination method

positive regulation of smoothened signaling pathway

determination method

1 reference

9 May 2019

Suppressing Wnt signaling by the hedgehog pathway through sFRP-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

lung development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

positive regulation of cell migration

determination method

1 reference

24 April 2018

A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08151&geneProductId=UniProtKB:P08151

determination method

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

notochord regression

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08151&geneProductId=UniProtKB:P08151

determination method

positive regulation of transcription, DNA-templated

determination method

4 references

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Physical and functional interactions between Zic and Gli proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Suppressing Wnt signaling by the hedgehog pathway through sFRP-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

positive regulation of DNA replication

determination method

1 reference

9 May 2019

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

ventral midline development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

multicellular organism development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

regulation of smoothened signaling pathway

determination method

1 reference

9 May 2019

Physical and functional interactions between Zic and Gli proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

liver regeneration

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

response to wounding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

regulation of osteoblast differentiation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

osteoblast differentiation

determination method

1 reference

9 May 2019

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

spermatogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

cerebellar cortex morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

regulation of hepatocyte proliferation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

canonical Wnt signaling pathway

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

smoothened signaling pathway

determination method

4 references

9 May 2019

The sonic hedgehog-patched-gli pathway in human development and disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

dorsal/ventral pattern formation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

negative regulation of canonical Wnt signaling pathway

determination method

1 reference

9 May 2019

Suppressing Wnt signaling by the hedgehog pathway through sFRP-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

positive regulation of transcription by RNA polymerase II

determination method

4 references

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

9 May 2019

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

digestive tract morphogenesis

determination method

1 reference

9 May 2019

The sonic hedgehog-patched-gli pathway in human development and disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

prostate gland development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

positive regulation of cardiac muscle cell proliferation

determination method

1 reference

9 May 2019

miR-873 suppresses H9C2 cardiomyocyte proliferation by targeting GLI1.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

positive regulation of cell cycle G1/S phase transition

determination method

1 reference

9 May 2019

miR-873 suppresses H9C2 cardiomyocyte proliferation by targeting GLI1.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

positive regulation of cell population proliferation

determination method

1 reference

9 May 2019

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08151

determination method

Gene Atlas image

PBB GE GLI1 206646 at fs.png
732 × 530; 12 KB

0 references

Zinc finger C2H2-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08151

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000228682

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000228682

ENSP00000434408

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434408

ENSP00000437607

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000437607

ENSP00000441006

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000441006

ENSP00000434421

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434421

ENSP00000436671

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000436671

PDB structure ID

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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