Gamma-aminobutyric acid type A receptor subunit alpha4 (Q5512777)

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mammalian protein found in Homo sapiens

gamma-aminobutyric acid receptor subunit alpha-4
GABA(A) receptor subunit alpha-4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRA4
gamma-aminobutyric acid type A receptor alpha4 subunit
gamma-aminobutyric acid A receptor alpha 4
GABA(A) receptor, alpha 4

Language	Label	Description	Also known as
English	Gamma-aminobutyric acid type A receptor subunit alpha4	mammalian protein found in Homo sapiens	gamma-aminobutyric acid receptor subunit alpha-4 GABA(A) receptor subunit alpha-4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 GABRA4 gamma-aminobutyric acid type A receptor alpha4 subunit gamma-aminobutyric acid A receptor alpha 4 GABA(A) receptor, alpha 4

Statements

1 reference

13 November 2019

UniProt protein ID

Neurotransmitter-gated ion-channel ligand-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48169

Neurotransmitter-gated ion-channel transmembrane domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48169

Gamma-aminobutyric-acid A receptor, alpha 4 subunit

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48169

Neurotransmitter-gated ion-channel transmembrane domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Neurotransmitter-gated ion-channel ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Neurotransmitter-gated ion-channel, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

ion channel activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

benzodiazepine receptor activity

determination method

1 reference

16 July 2018

Cloning and characterization of the human GABAA receptor alpha 4 subunit: identification of a unique diazepam-insensitive binding site

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48169&geneProductId=UniProtKB:P48169

determination method

chloride channel activity

determination method

1 reference

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48169&geneProductId=UniProtKB:P48169

determination method

extracellular ligand-gated ion channel activity

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48169&geneProductId=UniProtKB:P48169

determination method

transmembrane signaling receptor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

inhibitory extracellular ligand-gated ion channel activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

GABA-gated chloride ion channel activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

GABA-A receptor complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

postsynaptic membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

determination method

2 references

determination method

1 reference

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48169&geneProductId=UniProtKB:P48169

determination method

integral component of plasma membrane

determination method

1 reference

16 July 2018

Cloning and characterization of the human GABAA receptor alpha 4 subunit: identification of a unique diazepam-insensitive binding site

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48169&geneProductId=UniProtKB:P48169

determination method

chloride channel complex

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

plasma membrane

determination method

2 references

GABA-ergic synapse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

integral component of postsynaptic specialization membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

dendrite membrane

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

neuron projection

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

biological process

chloride transmembrane transport

determination method

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48169&geneProductId=UniProtKB:P48169

determination method

regulation of response to drug

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

central nervous system development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

ion transmembrane transport

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48169&geneProductId=UniProtKB:P48169

determination method

signal transduction

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

gamma-aminobutyric acid signaling pathway

determination method

3 references

8 April 2019

Cloning and characterization of the human GABAA receptor alpha 4 subunit: identification of a unique diazepam-insensitive binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

chemical synaptic transmission

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

regulation of membrane potential

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

nervous system process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

synaptic transmission, GABAergic

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

regulation of postsynaptic membrane potential

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

chloride transmembrane transport

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48169

determination method

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

isonipecotic acid

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

allosteric modulator

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

allosteric modulator

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

channel blocker

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

object has role

positive allosteric modullator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL450

object has role

positive modulator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201317

object has role

positive allosteric modullator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL454

chlordiazepoxide

object has role

positive allosteric modullator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451

object has role

positive allosteric modullator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL12

object has role

positive allosteric modullator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL969

object has role

positive allosteric modullator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL135400

object has role

positive modulator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL220492

object has role

positive allosteric modullator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1697737

allopregnanolone

object has role

positive allosteric modullator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL38856

chlordiazepoxide hydrochloride

object has role

positive allosteric modullator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200703

clorazepate dipotassium

object has role

positive allosteric modullator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2096631

methohexital sodium

object has role

positive allosteric modullator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL30219

pentobarbital sodium

object has role

positive allosteric modullator

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL971

Gene Atlas image

PBB GE GABRA4 208463 at fs.png
732 × 530; 12 KB

0 references

Neurotransmitter-gated ion-channel transmembrane domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48169

Neurotransmitter-gated ion-channel ligand-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48169

Neurotransmitter-gated ion-channel, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48169

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000264318

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000264318

ENSP00000422152

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422152

ENSP00000424386

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424386

ENSP00000425445

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425445

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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