Class II major histocompatibility complex transactivator (Q5011707)

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mammalian protein found in Homo sapiens

nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
MHC class II transactivator
MHC class II transactivator type I
CIITA
MHC class II transactivator type III
NLR family, acid domain containing

Language	Label	Description	Also known as
English	Class II major histocompatibility complex transactivator	mammalian protein found in Homo sapiens	nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing MHC class II transactivator MHC class II transactivator type I CIITA MHC class II transactivator type III NLR family, acid domain containing

Statements

1 reference

13 November 2019

UniProt protein ID

MHC class II transactivator

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33076

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33076

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33076

NACHT nucleoside triphosphatase family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

determination method

1 reference

8 April 2019

CATERPILLER: a novel gene family important in immunity, cell death, and diseases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

transcription coactivator activity

determination method

1 reference

8 April 2019

Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

protein C-terminus binding

determination method

1 reference

8 April 2019

ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

protein binding

determination method

4 references

8 April 2019

PML promotes MHC class II gene expression by stabilizing the class II transactivator

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

8 April 2019

ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

8 April 2019

The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

8 April 2019

SIRT1 links CIITA deacetylation to MHC II activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

acyltransferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

determination method

2 references

protein-containing complex binding

determination method

1 reference

8 April 2019

The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

biological process

positive regulation of MHC class II biosynthetic process

determination method

1 reference

27 February 2018

The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33076&geneProductId=UniProtKB:P33076

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

response to interferon-gamma

determination method

1 reference

8 April 2019

HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

interferon-gamma-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

response to antibiotic

determination method

1 reference

8 April 2019

A quantitative study of the glia of the Purkinje cell layer of the cerebellum in mammals

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33076&geneProductId=UniProtKB:P33076

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

immune response

determination method

1 reference

8 April 2019

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

positive regulation of MHC class I biosynthetic process

determination method

1 reference

27 February 2018

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33076&geneProductId=UniProtKB:P33076

determination method

negative regulation of collagen biosynthetic process

determination method

1 reference

8 April 2019

HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

inflammatory response

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

8 April 2019

The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

8 April 2019

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33076

determination method

Gene Atlas image

PBB GE CIITA 211884 s at fs.png
732 × 530; 12 KB

0 references

http://purl.uniprot.org/uniprot/P33076

1 reference

Identifiers.org

Leucine-rich repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33076

NACHT nucleoside triphosphatase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33076

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

4 April 2020

1 reference

4 April 2020

1 reference

4 April 2020

1 reference

4 April 2020

1 reference

4 April 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000371257

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000371257

ENSP00000316328

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000316328

ENSP00000459608

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000459608

ENSP00000459829

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000459829

ENSP00000484761

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000484761

ENSP00000485010

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000485010

ENSP00000489907

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000489907

ENSP00000490205

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000490205

ENSP00000495431

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495431

ENSP00000496240

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496240

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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