inducible T cell costimulator (Q5009806)

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mammalian protein found in Homo sapiens

inducible costimulator
activation-inducible lymphocyte immunomediatory molecule
inducible T-cell costimulator
inducible T-cell co-stimulator
ICOS
Inducible T-Cell Co-Stimulator Protein

Language	Label	Description	Also known as
English	inducible T cell costimulator	mammalian protein found in Homo sapiens	inducible costimulator activation-inducible lymphocyte immunomediatory molecule inducible T-cell costimulator inducible T-cell co-stimulator ICOS Inducible T-Cell Co-Stimulator Protein

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

determination method

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6W8&geneProductId=UniProtKB:Q9Y6W8

determination method

protein binding

determination method

4 references

9 May 2019

A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

9 May 2019

ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

9 May 2019

Ligand binding sites of inducible costimulator and high avidity mutants with improved function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

9 May 2019

Structural basis of inducible costimulator ligand costimulatory function: determination of the cell surface oligomeric state and functional mapping of the receptor binding site of the protein.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

integral component of membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

extracellular region

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

integral component of plasma membrane

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

external side of plasma membrane

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

biological process

T cell tolerance induction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

immune response

determination method

1 reference

9 May 2019

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

phosphatidylinositol phosphate biosynthetic process

determination method

1 reference

7 November 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6W8&geneProductId=UniProtKB:Q9Y6W8

determination method

cell-cell adhesion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

positive regulation of protein kinase B signaling

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

T cell costimulation

determination method

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

Gene Atlas image

PBB GE ICOS 210439 at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/Q9Y6W8

1 reference

Identifiers.org

Identifiers

MeSH descriptor ID

subject named as

Inducible T-Cell Co-Stimulator Protein

0 references

D12.776.543.750.705.222.812

0 references

D23.050.301.264.894.580

0 references

D23.101.100.894.580

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000319476

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000319476

ENSP00000415951

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000415951

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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