G protein-coupled receptor kinase 2 (Q4897285)

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mammalian protein found in Homo sapiens

• beta-adrenergic receptor kinase 1
• adrenergic beta receptor kinase 1
• beta-ARK-1
• GRK2
• G-protein coupled receptor kinase 2

edit

Language	Label	Description	Also known as
English	G protein-coupled receptor kinase 2	mammalian protein found in Homo sapiens	beta-adrenergic receptor kinase 1 adrenergic beta receptor kinase 1 beta-ARK-1 GRK2 G-protein coupled receptor kinase 2

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P25098

part of

GPCR kinase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25098

Protein kinase-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25098

PH-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25098

RGS domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25098

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Regulator of G protein signalling

1 reference

based on heuristic

inferred from protein domain or family

AGC-kinase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P25098

encoded by

GRK2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P25098

molecular function

transferase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

Edg-2 lysophosphatidic acid receptor binding

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IDA

protein kinase activity

determination method

ISS

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

ISS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

nucleotide binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

G protein-coupled receptor kinase activity

determination method

ISS

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

ISS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

kinase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

protein serine/threonine kinase activity

determination method

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

protein binding

determination method

IPI

7 references

retrieved

8 April 2019

stated in

Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IPI

retrieved

8 April 2019

stated in

The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IPI

retrieved

8 April 2019

stated in

Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IPI

retrieved

8 April 2019

stated in

Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IPI

retrieved

8 April 2019

stated in

G protein-coupled receptor kinase 2 positively regulates epithelial cell migration

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IPI

retrieved

8 April 2019

stated in

Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IPI

retrieved

8 April 2019

stated in

Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IPI

alpha-2A adrenergic receptor binding

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

ISS

ATP binding

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

beta-adrenergic receptor kinase activity

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

cell component

cytoplasm

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

retrieved

8 April 2019

stated in

Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IDA

cytosol

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

TAS

membrane

determination method

IDA

ISS

IEA

4 references

retrieved

31 October 2017

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25098&geneProductId=UniProtKB:P25098

determination method

ISS

retrieved

31 October 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25098&geneProductId=UniProtKB:P25098

determination method

IEA

retrieved

31 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25098&geneProductId=UniProtKB:P25098

determination method

IEA

retrieved

31 October 2017

stated in

Defining the membrane proteome of NK cells

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25098&geneProductId=UniProtKB:P25098

determination method

IDA

plasma membrane

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

cilium

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

TAS

membrane

determination method

HDA

IEA

ISS

4 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

ISS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

retrieved

8 April 2019

stated in

Defining the membrane proteome of NK cells

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

HDA

biological process

G protein-coupled acetylcholine receptor signaling pathway

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

ISS

cardiac muscle contraction

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IMP

phosphorylation

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

regulation of the force of heart contraction

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

viral genome replication

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IMP

negative regulation of striated muscle contraction

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IMP

positive regulation of catecholamine secretion

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

ISS

receptor internalization

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2

GOA

curator

UniProt

UniProt protein ID

P25098

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IDA

tachykinin receptor signaling pathway

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IDA

protein phosphorylation

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

heart development

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

peptidyl-serine phosphorylation

determination method

ISS

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

viral entry into host cell

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IMP

desensitization of G protein-coupled receptor signaling pathway

determination method

ISS

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

peptidyl-threonine phosphorylation

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

negative regulation of the force of heart contraction by chemical signal

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IMP

signal transduction

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

G protein-coupled receptor signaling pathway

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25098

determination method

IEA

physically interacts with

balanol

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

8142

language of work or name

English

retrieved

17 August 2016

Gene Atlas image

PBB GE ADRBK1 38447 at fs.png
732 × 530; 12 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P25098

1 reference

stated in

Identifiers.org

has part(s)

RGS domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25098

AGC-kinase, C-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25098

pleckstrin homology domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25098

protein kinase, ATP binding site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25098

protein kinase domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25098

serine/threonine-protein kinase, active site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P25098

Identifiers

MeSH descriptor ID

D054769

subject named as

G-Protein-Coupled Receptor Kinase 2

0 references

MeSH tree code

D08.811.913.696.620.682.700.364.049.200

0 references

D12.776.476.563.364.049.200

0 references

RefSeq protein ID

NP_001610

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

156

XP_011543075

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

156

XP_024304144

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

156

UniProt protein ID

P25098

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P25098

Ensembl protein ID

ENSP00000312262

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000312262

ENSP00000434126

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000434126

PDB structure ID

4PNK

1 reference

stated in

UniProt

UniProt protein ID

P25098

retrieved

4 August 2016

language of work or name

English

1BAK

1 reference

stated in

UniProt

UniProt protein ID

P25098

retrieved

4 August 2016

language of work or name

English

3CIK

1 reference

stated in

UniProt

UniProt protein ID

P25098

retrieved

4 August 2016

language of work or name

English

3KRW

1 reference

stated in

UniProt

UniProt protein ID

P25098

retrieved

4 August 2016

language of work or name

English

3KRX

1 reference

stated in

UniProt

UniProt protein ID

P25098

retrieved

4 August 2016

language of work or name

English

3V5W

1 reference

stated in

UniProt

UniProt protein ID

P25098

retrieved

4 August 2016

language of work or name

English

4MK0

1 reference

stated in

UniProt

UniProt protein ID

P25098

retrieved

4 August 2016

language of work or name

English

5HE1

1 reference

stated in

UniProt

UniProt protein ID

P25098

retrieved

4 August 2016

language of work or name

English

 

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Wikiquote(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q4897285&oldid=2117504121"